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PMID: 3033666 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Avian sarcoma virus 17 carries the jun oncogene.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 9 ·1987-05-00 ·Pages 2848-52

Maki Y, Bos TJ, Davis C, Starbuck M, Vogt PK

Abstract

Biologically active molecular clones of avian sarcoma virus 17 (ASV 17) contain a replication-defective proviral genome of 3.5 kilobases (kb). The genome retains partial gag and env sequences, which flank a cell-derived putative oncogene of 0.93 kb, termed jun. The jun gene lacks preserved coding domains of tyrosine-specific protein kinases. It also shows no significant nucleic acid homology with other known oncogenes. The probable transformation-specific protein in ASV 17-transformed cells is a 55-kDa gag-jun fusion product.

MeSH Terms
Amino Acid Sequence Animals Avian Sarcoma Viruses/genetics Base Sequence Cell Transformation, Neoplastic Cells, Cultured Chick Embryo DNA Restriction Enzymes Genes, Viral Nucleic Acid Hybridization Oncogene Proteins, Viral/genetics Oncogenes Transfection
Chemicals
Oncogene Proteins, Viral DNA Restriction Enzymes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Maki Y
Bos T J
Davis C
Starbuck M
Vogt P K
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10 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.9.2848
Published
1987-05-00
Pages
2848-52
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC304757
Subset
IM
Grants
NCI NIH HHS · CA 13213 · United States
NCI NIH HHS · CA 29777 · United States
NCI NIH HHS · CA 42564 · United States
Databases
GENBANK
M16266
External Links
PubMed source DOI: 10.1073/pnas.84.9.2848 PMC Full Text View journal details
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