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PMID: 3035230 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro.

Journal of virology ·Vol. 61 ·No. 7 ·1987-07-00 ·Pages 2311-5

Wilcox CL, Johnson EM

Abstract

Primary sympathetic neuronal cultures were maintained for up to 5 weeks after inoculation with herpes simplex virus (HSV) without evidence of viral infection. Upon deprivation of nerve growth factor, the cultures produced infectious HSV, indicating that the cultures harbored latent HSV. This study demonstrates a function of nerve growth factor in the maintenance of HSV latency.

MeSH Terms
Animals Herpes Simplex/physiopathology Nerve Growth Factors/pharmacology,physiology Neurons/microbiology Rats Simplexvirus/drug effects,isolation & purification,physiology Virus Activation/drug effects
Chemicals
Nerve Growth Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilcox C L
Johnson E M
References (33)
33 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.61.7.2311-2315.1987
Published
1987-07-00
Pages
2311-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC283698
Subset
IM
Grants
NHLBI NIH HHS · 5-T32-HL07275 · United States
NINDS NIH HHS · NS 18071 · United States
External Links
PubMed source DOI: 10.1128/JVI.61.7.2311-2315.1987 PMC Full Text View journal details
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