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PMID: 3036997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.

The Journal of experimental medicine ·Vol. 166 ·No. 2 ·1987-08-01 ·Pages 341-61

Transy C, Nash SR, David-Watine B, Cochet M, Hunt SW, Hood LE, Kourilsky P

Abstract

We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.

MeSH Terms
Animals Base Sequence Chromosome Mapping DNA Restriction Enzymes Genes, MHC Class II H-2 Antigens/genetics Mice Mice, Inbred BALB C/genetics Polymorphism, Genetic RNA, Messenger/analysis Tissue Distribution
Chemicals
H-2 Antigens RNA, Messenger DNA Restriction Enzymes
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Transy C
Nash S R
David-Watine B
Cochet M
Hunt S W
Hood L E
Kourilsky P
References (46)
46 references, click to expand
  1. Epstein Barr virus selective T cells in infectious mononucleosis are not restricted to HLA-A and B antigens.
    J Immunol. 1981 Jul;127(1):293-300 PMID: 6263974
  2. Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3201-5 PMID: 6932015
  3. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.
    Cell. 1981 Sep;25(3):683-92 PMID: 6895187
  4. Absence of significant H-2 and beta 2-microglobulin mRNA expression by mouse embryonal carcinoma cells.
    Nature. 1982 Mar 18;296(5854):260-2 PMID: 6174872
  5. Clusters of genes encoding mouse transplantation antigens.
    Cell. 1982 Mar;28(3):489-98 PMID: 6280871
  6. Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.
    Proc Natl Acad Sci U S A. 1982 Jul;79(14):4395-9 PMID: 6981813
  7. Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes (CTL): possible implications for the affinity of CTL antigen receptors.
    Immunol Rev. 1982;68:89-115 PMID: 6184308
  8. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
    Anal Biochem. 1984 Feb;137(1):266-7 PMID: 6329026
  9. Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.
    Nature. 1984 Aug 23-29;310(5979):650-5 PMID: 6088985
  10. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.
    Nucleic Acids Res. 1984 Sep 25;12(18):7035-56 PMID: 6091052
  11. Rapid restriction mapping of DNA cloned in lambda phage vectors.
    Gene. 1984 Oct;30(1-3):195-200 PMID: 6096214
  12. DNA sequence of the mouse H-2Dd transplantation antigen gene.
    Proc Natl Acad Sci U S A. 1985 Feb;82(4):1175-9 PMID: 3856254
  13. Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver.
    Cell. 1985 Jun;41(2):469-78 PMID: 3838699
  14. Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.
    J Exp Med. 1985 Aug 1;162(2):528-45 PMID: 3894562
  15. Structural analysis of TL genes of the mouse.
    Proc Natl Acad Sci U S A. 1985 Aug;82(16):5475-9 PMID: 2410925
  16. Intron sequences reveal evolutionary relationships among major histocompatibility complex class I genes.
    Proc Natl Acad Sci U S A. 1985 Sep;82(17):5860-4 PMID: 3862103
  17. Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.
    J Exp Med. 1985 Oct 1;162(4):1134-48 PMID: 3840195
  18. Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.
    J Exp Med. 1985 Nov 1;162(5):1588-602 PMID: 2997361
  19. Rapid transfer of DNA from agarose gels to nylon membranes.
    Nucleic Acids Res. 1985 Oct 25;13(20):7207-21 PMID: 4059056
  20. Genes of the major histocompatibility complex of the mouse.
    Annu Rev Immunol. 1983;1:529-68 PMID: 6152713
  21. Polymorphism in mouse and human class I H-2 and HLA genes is not the result of random independent point mutations.
    Immunogenetics. 1985;22(5):453-70 PMID: 3934067
  22. Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression.
    Cell. 1986 Jan 31;44(2):261-72 PMID: 3510743
  23. Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.
    Proc Natl Acad Sci U S A. 1986 Mar;83(6):1782-6 PMID: 3456611
  24. Organization and evolution of D region class I genes in the mouse major histocompatibility complex.
    J Exp Med. 1986 May 1;163(5):1227-44 PMID: 3701254
  25. A speculative view of the multicomponent nature of T cell antigen recognition.
    Cell. 1986 May 23;45(4):475-84 PMID: 3085952
  26. A trans-acting mechanism represses the expression of the major transplantation antigens in mouse hybrid thymoma cell lines.
    J Exp Med. 1986 Sep 1;164(3):677-94 PMID: 3746199
  27. Ubiquitous transposon-like repeats B1 and B2 of the mouse genome: B2 sequencing.
    Nucleic Acids Res. 1982 Dec 11;10(23):7461-75 PMID: 6296779
  28. A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen.
    Nucleic Acids Res. 1983 Mar 11;11(5):1567-77 PMID: 6298749
  29. Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex.
    Proc Natl Acad Sci U S A. 1983 Jun;80(11):3425-9 PMID: 6304710
  30. T cell subsets and the recognition of MHC class.
    Immunol Rev. 1983;74:129-42 PMID: 6226585
  31. A method for isolation of intact, translationally active ribonucleic acid.
    DNA. 1983;2(4):329-35 PMID: 6198133
  32. Mouse histocompatibility genes: structure and organisation of a Kd gene.
    EMBO J. 1983;2(2):245-54 PMID: 11894934
  33. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  34. A general method for isolation of high molecular weight DNA from eukaryotes.
    Nucleic Acids Res. 1976 Sep;3(9):2303-8 PMID: 987581
  35. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.
    Cell. 1977 May;11(1):223-32 PMID: 194704
  36. Cytotoxicity against tumour-associated antigens not H-2 restricted.
    Nature. 1977 Jul 21;268(5617):250-2 PMID: 69992
  37. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  38. The major histocompatibility complex of the mouse.
    Science. 1979 Feb 9;203(4380):516-21 PMID: 104386
  39. H-2 restriction and non-restriction of T-cell-mediated cytotoxicity against mouse mammary tumour targets.
    Nature. 1978 Nov 9;276(5684):181-2 PMID: 216918
  40. Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera.
    Proc Natl Acad Sci U S A. 1979 Apr;76(4):1977-81 PMID: 88050
  41. An immunoglobulin heavy-chain gene is formed by at least two recombinational events.
    Nature. 1980 Feb 21;283(5749):733-9 PMID: 6766532
  42. Antigenic specificity of the cytolytic T lymphocyte (CTL) response to murine sarcoma virus-induced tumors. II. Analysis of the clonal progeny of CTL precursors stimulated in vitro with syngeneic tumor cells.
    J Immunol. 1980 Apr;124(4):1627-34 PMID: 6154076
  43. Expression of fetal and neonatal hepatic functions by mouse hepatoma-rat hepatoma hybrids.
    Somatic Cell Genet. 1979 Nov;5(6):719-38 PMID: 545721
  44. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
    Eur J Biochem. 1980 Jun;107(2):303-14 PMID: 6772444
  45. Mouse alloantibodies capable of blocking cytotoxic T cell function. II. Further study on the relationship between the blocking antibodies and the products of the Lyt-2 locus.
    Eur J Immunol. 1980 Aug;10(8):589-94 PMID: 6967414
  46. Organization and expression of eucaryotic split genes coding for proteins.
    Annu Rev Biochem. 1981;50:349-83 PMID: 6791577
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.166.2.341
Published
1987-08-01
Pages
341-61
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189607
Subset
IM
Databases
GENBANK
Y00629
External Links
PubMed source DOI: 10.1084/jem.166.2.341 PMC Full Text View journal details
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