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PMID: 3053661 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

An in vivo complex with DNA photolyase blocks UV mutagenesis targeted at a thymine-cytosine dimer in Escherichia coli.

Journal of bacteriology ·Vol. 170 ·No. 11 ·1988-11-00 ·Pages 5371-4

Ruiz-Rubio M, Yamamoto K, Bockrath R

Abstract

UV mutation frequency responses for two types of Escherichia coli prototrophic mutant were measured. Only the response associated with a mutation targeted by a thymine-cytosine pyrimidine dimer was reduced in the dark in cells with amplified DNA photolyase. This specific reduction is attributed to the interruption of mutational DNA synthesis by a photolyase complex at the targeting dimer.

MeSH Terms
Deoxyribodipyrimidine Photo-Lyase/metabolism Dose-Response Relationship, Radiation Escherichia coli/enzymology,genetics,radiation effects Lyases/metabolism Mutation Pyrimidine Dimers Transcription, Genetic Ultraviolet Rays
Chemicals
Pyrimidine Dimers Lyases Deoxyribodipyrimidine Photo-Lyase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ruiz-Rubio M
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46223.
Yamamoto K
Bockrath R
References (21)
21 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.170.11.5371-5374.1988
Published
1988-11-00
Pages
5371-4
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC211616
Subset
IM
Grants
NIGMS NIH HHS · GM21789 · United States
External Links
PubMed source DOI: 10.1128/jb.170.11.5371-5374.1988 PMC Full Text View journal details
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