Mutagenic repair in Escherichia coli. X. The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV-mutagenesis.

Molecular & general genetics : MGG ·Vol. 196 ·No. 2 ·1984-00-00 ·Pages 364-6

Bridges BA, Woodgate R

Abstract

Bacteria of strain TK610 uvrA-6 his-4 umuC-36, when allowed to replicate their DNA for some hours after irradiation show induction of His+ mutations when subsequently exposed to visible light. It is suggested that base pair errors can be made opposite sites of pyrimidine dimers without involvement of umuC gene product but that the latter is required for continued replication past the dimer-mismatch region. Removal of the pyrimidine dimer by photoreversal allows replication to continue thus fixing the mismatched base as as mutation.

MeSH Terms

Bacterial Proteins/genetics,physiology DNA Repair DNA Replication DNA, Bacterial/genetics,radiation effects Escherichia coli/genetics Mutation Pyrimidine Dimers/metabolism Ultraviolet Rays

Chemicals

Bacterial Proteins DNA, Bacterial Pyrimidine Dimers

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bridges B A

Woodgate R

References (17)

17 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00328073

Published

1984-00-00

Pages

364-6

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00328073

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Mutagenic repair in Escherichia coli. X. The umuC gene product may be required for replication past pyrimidine dimers but not for the coding error in UV-mutagenesis.

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