Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 41 ·No. 4 ·1978-04-00 ·Pages 307-11

Shakir RA, Behan PO, Dick H, Lambie DG

Abstract

Low serum IgA levels were found in patients taking phenytoin, together with evidence of depressed T cell function. There was no correlation between the dose or the serum level. A correlation was found, however, with HL-A status, patients with a low IgA showing increased frequency of HL-A2. It is suggested that epileptic patients with HL-A2 status are likely to develop IgA deficiency when given phenytoin.

MeSH Terms

Adolescent Adult Aged Blood Proteins/biosynthesis Epilepsy/drug therapy Female Folic Acid/blood HLA Antigens Humans Immunologic Deficiency Syndromes/chemically induced,immunology,metabolism Lectins/pharmacology Lymphocytes/metabolism Male Middle Aged Phenytoin/adverse effects T-Lymphocytes/immunology

Chemicals

Blood Proteins HLA Antigens Lectins Phenytoin Folic Acid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Shakir R A

Behan P O

Dick H

Lambie D G

References (17)

17 references, click to expand

Inhibition of transformation of normal lymphocytes by plasma factor from patients with Hodgkin's disease and cancer.
Lancet. 1971 Dec 4;2(7736):1265 PMID: 4143624
Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).
Lancet. 1971 Dec 4;2(7736):1233-5 PMID: 4143595
Immunological abnormalities in patients who had the oculomucocutaneous syndrome associated with practolol therapy.
Lancet. 1976 Nov 6;2(7993):984-7 PMID: 62263
Hypogammaglobulinemia, primary and secondary: immunoglobulin levels (gamma-G, gamma-A, gamma-M) in one hundred and twenty-five patients.
J Allergy. 1966 Oct;38(4):215-25 PMID: 4162597
Is phenytoin carcinogenic?
Lancet. 1972 Feb 5;1(7745):323 PMID: 4109962
Immune imbalance in dysgammaglobulinaemia type IV.
Lancet. 1968 Jan 20;1(7534):110-4 PMID: 4169601
Abnormalities in IgA-containing mononuclear cells in the gastric lesion of pernicious anaemia.
Lancet. 1968 Oct 19;2(7573):846-9 PMID: 4175742
Human immunoglobulin A.
N Engl J Med. 1968 Dec 12;279(24):1327-30 PMID: 4177113
IgA deficiency, epilepsy, and hydantoin medication.
Lancet. 1976 Jul 31;2(7979):228-31 PMID: 59243
Letter: Impaired cell-mediated immunity in human brain tumours.
Lancet. 1975 Jun 21;1(7921):1389-90 PMID: 48983
Surface immunoglobulins on the thoracic duct lymphocytes of the congenitally athymic (nude) mouse.
Aust J Exp Biol Med Sci. 1972 Oct;50(5):661-4 PMID: 4539886
Folic acid deficiency and epilepsy.
Drugs. 1974;8(5):366-85 PMID: 4455477
Studies on the nature of autoimmunity in myasthenia gravis. Evidence for an immunodeficiency type.
Ann N Y Acad Sci. 1976;274:382-9 PMID: 134659
Serum immunoglobulins in epilepsy.
J Neurol Sci. 1974 Nov;23(3):353-7 PMID: 4427121
A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector.
Clin Chim Acta. 1973 Feb 12;43(3):423-9 PMID: 4690913
Immunological abnormalities and hydantoins.
Br Med J. 1972 Jun 3;2(5813):561-3 PMID: 5032783
Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro.
Clin Exp Immunol. 1975 May;20(2):273-85 PMID: 1212810

Article Info

Journal

Journal of neurology, neurosurgery, and psychiatry

Abbr.

J Neurol Neurosurg Psychiatry

ISSN

0022-3050

DOI

10.1136/jnnp.41.4.307

Published

1978-04-00

Pages

307-11

Language

English

Region

England

NLM ID

2985191R

PMCID

PMC493022

Subset

External Links

PubMed source DOI: 10.1136/jnnp.41.4.307 PMC Full Text View journal details

Analysis Services

Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.

Contact

WeChat Official Account