Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization.

Infection and immunity ·Vol. 21 ·No. 1 ·1978-07-00 ·Pages 206-12

Hillman JD

Abstract

Mutants of Streptococcus mutans were isolated which lack the enzyme activity L (+)-lactate dehydrogenase. Reversion studies indicate that the genetic defects are in the structural gene for the enzyme. The mutants produce less titratable acid from glucose, adhere better to hydroxyapatite, and accumulate more plaque when grown in the presence of sucrose than does the parent strain. These findings suggest a possible use for the mutants as effector strains in the replacement therapy of dental caries.

MeSH Terms

Adhesiveness Dental Plaque Glucose/metabolism Hydrogen-Ion Concentration Hydroxyapatites L-Lactate Dehydrogenase/metabolism Lactates/metabolism Mutation Streptococcus mutans/enzymology,genetics,metabolism

Chemicals

Hydroxyapatites Lactates L-Lactate Dehydrogenase Glucose

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hillman J D

References (29)

29 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.21.1.206-212.1978

Published

1978-07-00

Pages

206-12

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421978

Subset

External Links

PubMed source DOI: 10.1128/iai.21.1.206-212.1978 PMC Full Text View journal details

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Lactate dehydrogenase mutants of Streptococcus mutans: isolation and preliminary characterization.

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