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PMID: 3094064 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dopamine autoreceptors in the ventral tegmental area show subsensitivity following withdrawal from chronic antidepressant drug treatment.

Psychopharmacology ·Vol. 90 ·No. 1 ·1986-00-00 ·Pages 64-71

Towell A, Willner P, Muscat R

Abstract

The suppression by apomorphine of food intake and eating time was used to assay the sensitivity of dopamine cell body autoreceptors during the course of treatment with DMI, amitriptyline and mianserin. Brief (2-4 days) DMI treatment enhanced the effects of apomorphine, administered systemically or centrally to DA cell body regions. During chronic DMI treatment (3-7 weeks) some evidence of autoreceptor subsensitivity was observed with systemic apomorphine, but not with central apomorphine. Responses to apomorphine applied systemically were reduced during withdrawal from chronic DMI, and responses to apomorphine applied to the ventral tegmental area were reduced during withdrawal from all three antidepressants. As evidence of DA autoreceptor subsensitivity was only observed reliably during withdrawal, this effect is unlikely to be of clinical importance.

MeSH Terms
Animals Antidepressive Agents/pharmacology Apomorphine/pharmacology Desipramine/pharmacology Feeding Behavior/drug effects Male Rats Receptors, Dopamine/metabolism Substance Withdrawal Syndrome/metabolism Tegmentum Mesencephali/metabolism
Chemicals
Antidepressive Agents Receptors, Dopamine Apomorphine Desipramine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Towell A
Willner P
Muscat R
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26 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00172873
Published
1986-00-00
Pages
64-71
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00172873 View journal details
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