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PMID: 3104601 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Molecular evolution of the carbonic anhydrase genes: calculation of divergence time for mouse carbonic anhydrase I and II.

Journal of molecular evolution ·Vol. 23 ·No. 4 ·1986-00-00 ·Pages 294-9

Fraser PJ, Curtis PJ

Abstract

A cDNA clone in pBR322 that cross-hybridizes with a mouse carbonic anhydrase form II (CAII) probe has been sequenced and identified as mouse carbonic anhydrase form I (CAI). The 1224-base-pair clone encodes the entire 260-amino-acid protein and appears to contain an Alu-like element in the 3' untranslated region. The deduced amino acid sequence exhibits 77% homology to human CAI and contains 17 of the 20 residues that are considered unique to and invariant for all mammalian CAI isozymes. The results of a detailed comparison of the nucleic acid sequences spanning the coding regions of mouse CAI and rabbit CAI have been used to calibrate an evolutionary clock for the carbonic anhydrases (CAs). These data have been applied to a comparison of the mouse CAI and CAII nucleic acid sequences to calculate the divergence time between the two genes. The divergence-time calculation provides the first estimation of the evolutionary relationship between CAs based entirely on nucleotide sequence comparison.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Biological Evolution Carbonic Anhydrases/blood,genetics Cloning, Molecular DNA/metabolism Erythrocytes/enzymology Erythropoiesis Genes Genetic Variation Mice
Chemicals
DNA Carbonic Anhydrases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fraser P J
Curtis P J
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02100637
Published
1986-00-00
Pages
294-9
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
Grants
NCI NIH HHS · CA-10815 · United States
External Links
PubMed source DOI: 10.1007/BF02100637 View journal details
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