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PMID: 31354629 Published · epublish English Journal Article Review

Proteomics for the Identification of Biomarkers in Testicular Cancer-Review.

Frontiers in endocrinology ·Vol. 10 ·2019-00-00 ·Pages 462

Milardi D, Grande G, Vincenzoni F, Pierconti F, Pontecorvi A

Abstract

A large number of biomarkers have been proposed for the diagnosis of testicular cancer, representing putative molecular targets for anticancer treatments. However, no conclusive data have been provided. Proteomics represents a research field recently developed. It evaluates the large-scale analysis of the full protein components of a single cell, of a specific tissue, or of biological fluids. In the last decades, proteomics has been applied in clinical fields, thanks to modern technology and new bioinformatic tools, to identify novel molecular markers of diseases. The aim of this review is to argue the findings of recent studies in the discoveries of putative prognostic and diagnostic markers of testis cancer by proteomic techniques. We present here a panel of proteins identified by proteomics which might be used after validation for early detection and the prognostic evaluation of testicular tumors. In addition, the molecular mechanisms revealed by these proteomic studies might also guide the development of novel treatments in future.

Keywords
biomarker germ cell tumor proteins proteomics testis cancer
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Milardi Domenico
International Scientific Institute "Paul VI", Rome, Italy. | Division of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, Italy.
Grande Giuseppe
International Scientific Institute "Paul VI", Rome, Italy. | Division of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, Italy.
Vincenzoni Federica
School of Medicine, Biochemistry and Clinical Biochemistry Institute, Catholic University of Rome, Rome, Italy. | Department of Laboratory Diagnostic and Infectious Diseases, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, Italy.
Pierconti Francesco
Division of Anatomic Pathology and Histology, School of Medicine, Catholic University of Rome, Rome, Italy.
Pontecorvi Alfredo
International Scientific Institute "Paul VI", Rome, Italy. | Division of Endocrinology, Fondazione Policlinico'A. Gemelli' IRCCS, Rome, Italy.
References (40)
40 references, click to expand
  1. 2D or not 2D. Two-dimensional gel electrophoresis.
    Curr Opin Chem Biol. 2001 Feb;5(1):26-33 PMID: 11166644
  2. Two-dimensional gel electrophoresis in proteomics: old, old fashioned, but it still climbs up the mountains.
    Proteomics. 2002 Jan;2(1):3-10 PMID: 11788986
  3. Polymorphism of human mu class glutathione transferases.
    Pharmacogenetics. 2004 Jun;14(6):359-68 PMID: 15247628
  4. EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B.
    Cell Death Differ. 2004 Dec;11(12):1299-308 PMID: 15332117
  5. The Orbitrap: a new mass spectrometer.
    J Mass Spectrom. 2005 Apr;40(4):430-43 PMID: 15838939
  6. Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects.
    Hum Reprod Update. 2006 May-Jun;12(3):303-23 PMID: 16540528
  7. Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue.
    Biol Chem. 2006 Apr;387(4):437-40 PMID: 16606342
  8. Dynamic range of mass accuracy in LTQ Orbitrap hybrid mass spectrometer.
    J Am Soc Mass Spectrom. 2006 Jul;17(7):977-982 PMID: 16750636
  9. HPLC techniques for proteomics analysis--a short overview of latest developments.
    Brief Funct Genomic Proteomic. 2006 Dec;5(4):249-60 PMID: 17124183
  10. Seminal fluid characterization for male fertility and prostate cancer: kallikrein-related serine proteases and whole proteome approaches.
    Semin Thromb Hemost. 2007 Feb;33(1):87-99 PMID: 17253195
  11. Use of SELDI-TOF mass spectrometry for identification of new biomarkers: potential and limitations.
    Clin Chem Lab Med. 2007;45(11):1435-49 PMID: 17970700
  12. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population.
    Am J Obstet Gynecol. 2008 Mar;198(3):303.e1-6 PMID: 18177825
  13. Expression and localization of StarD7 in trophoblast cells.
    Placenta. 2008 May;29(5):396-404 PMID: 18378304
  14. Centrosome amplification can initiate tumorigenesis in flies.
    Cell. 2008 Jun 13;133(6):1032-42 PMID: 18555779
  15. Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk.
    Arch Toxicol. 2009 Apr;83(4):351-6 PMID: 18668224
  16. Mass spectrometry for proteomics.
    Curr Opin Chem Biol. 2008 Oct;12(5):483-90 PMID: 18718552
  17. T-SP1: a novel serine protease-like protein predominantly expressed in testis.
    Biol Chem. 2008 Dec;389(12):1495-504 PMID: 18844450
  18. Proteomics by mass spectrometry: approaches, advances, and applications.
    Annu Rev Biomed Eng. 2009;11:49-79 PMID: 19400705
  19. A mechanism linking extra centrosomes to chromosomal instability.
    Nature. 2009 Jul 9;460(7252):278-82 PMID: 19506557
  20. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: serum protein profiling in seminoma patients.
    World J Urol. 2010 Apr;28(2):193-7 PMID: 19529944
  21. Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology.
    Pharmacogenet Genomics. 2009 Oct;19(10):751-9 PMID: 19741569
  22. Identification of nuclear structural protein alterations associated with seminomas.
    J Cell Biochem. 2009 Dec 15;108(6):1274-9 PMID: 19795381
  23. Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis.
    Zoolog Sci. 2009 Apr;26(4):294-300 PMID: 19798924
  24. Coupling liquid chromatography to Orbitrap mass spectrometry.
    J Chromatogr A. 2010 Jun 18;1217(25):3938-45 PMID: 20299023
  25. Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.
    Carcinogenesis. 2012 Jan;33(1):108-12 PMID: 22045029
  26. Scanning of novel cancer/testis proteins by human testis proteomic analysis.
    Proteomics. 2013 Apr;13(7):1200-10 PMID: 23436708
  27. A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes.
    J Biol Chem. 1990 Jun 5;265(16):9188-93 PMID: 2345169
  28. Proteomics of human seminal plasma: identification of biomarker candidates for fertility and infertility and the evolution of technology.
    Mol Reprod Dev. 2013 May;80(5):350-7 PMID: 23559416
  29. Classification, epidemiology and therapies for testicular germ cell tumours.
    Int J Dev Biol. 2013;57(2-4):133-9 PMID: 23784823
  30. Pituitary-tumour-transforming-gene 1 expression in testicular cancer.
    Andrologia. 2015 May;47(4):427-32 PMID: 24754453
  31. Novel biomarkers of androgen deficiency from seminal plasma profiling using high-resolution mass spectrometry.
    J Clin Endocrinol Metab. 2014 Aug;99(8):2813-20 PMID: 24796927
  32. Proteomics in cancer research: Are we ready for clinical practice?
    Crit Rev Oncol Hematol. 2015 Dec;96(3):437-48 PMID: 26277237
  33. Correlation Between Poor Prognosis and Lower TPPP Gene Expression in Hepatocellular Carcinoma.
    Anticancer Res. 2016 Sep;36(9):4639-45 PMID: 27630306
  34. Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2.
    Mol Cancer Ther. 2017 Oct;16(10):2292-2303 PMID: 28663269
  35. Expression patterns of HENMT1 and PIWIL1 in human testis: implications for transposon expression.
    Reproduction. 2017 Oct;154(4):363-374 PMID: 28676534
  36. Semen Proteomics Reveals the Impact of Enterococcus faecalis on male Fertility.
    Protein Pept Lett. 2018;25(5):472-477 PMID: 29651938
  37. Protein expression of the transcription factors DMRT1, TCLF5, and OCT4 in selected germ cell neoplasms of the testis.
    Hum Pathol. 2018 Dec;82:68-75 PMID: 30067948
  38. The diagnostic performance of current tumour markers in surveillance for recurrent testicular cancer: A diagnostic test accuracy systematic review.
    Cancer Epidemiol. 2019 Apr;59:15-21 PMID: 30658216
  39. Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer.
    Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S132-S144 PMID: 30683686
  40. Differential expression of glutathione S-transferases in germ cell tumors of human testes.
    Anticancer Res. 1998 May-Jun;18(3A):1727-31 PMID: 9673396
Article Info
Journal
Frontiers in endocrinology
Abbr.
Front Endocrinol (Lausanne)
ISSN
1664-2392
DOI
10.3389/fendo.2019.00462
Published
2019-00-00
Epub
2019-00-12
Pages
462
Language
English
Region
Switzerland
NLM ID
101555782
PMCID
PMC6639829
External Links
PubMed source DOI: 10.3389/fendo.2019.00462 PMC Full Text View journal details
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