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PMID: 3136013 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Immunoglobulin mRNA stability varies during B lymphocyte differentiation.

The EMBO journal ·Vol. 7 ·No. 4 ·1988-04-00 ·Pages 1041-6

Jäck HM, Wabl M

Abstract

During differentiation of B lymphocytes, the change in the amount of immunoglobulin heavy chain produced is reflected by a change in the steady state level of heavy chain mRNA. At the pre-B cell stage, the earliest stage at which immunoglobulin chain is produced, and later at the small resting B cell stage, there is a low steady state level of heavy chain mRNA. After the small B cell has differentiated to become a plasma cell, the steady state level of heavy chain mRNA is much higher. We confirm that the transcription rate at the immunoglobulin mu heavy chain gene does not change during differentiation from the pre-B cell to the plasma cell stage. In contrast, we show here that differences in the stability of mu mRNA are sufficient to account for the differences in the steady state level at the various differentiation stages.

MeSH Terms
B-Lymphocytes/cytology,immunology Cell Differentiation Cell Line Genes, Immunoglobulin Humans Immunoglobulin Heavy Chains/genetics Immunoglobulin mu-Chains/genetics RNA, Messenger/genetics Transcription, Genetic
Chemicals
Immunoglobulin Heavy Chains Immunoglobulin mu-Chains RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jäck H M
Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143-0750.
Wabl M
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-04-00
Pages
1041-6
Language
English
Region
England
NLM ID
8208664
PMCID
PMC454432
Subset
IM
Grants
NIGMS NIH HHS · 1 R01 GM37699-01A1 · United States
External Links
PubMed source PMC Full Text View journal details
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