Home LiteratureArticle Details
PMID: 3143103 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Specific and ubiquitous expression of different Zn finger protein genes in the mouse.

Nucleic acids research ·Vol. 16 ·No. 21 ·1988-11-11 ·Pages 9995-10011

Chowdhury K, Rohdewohld H, Gruss P

Abstract

Zinc finger proteins (Zfp) are members of a multigene family encoding Zn mediated nucleic acid binding proteins. They have been isolated from various organisms including yeast, Drosophila, Xenopus mouse and human. All Zfp share the 28-30 amino acid long finger repeats containing conserved residues at specific positions. Some of these proteins have been identified as transcriptional regulatory factors. In this paper, we describe the isolation, DNA sequence determination and the expression pattern in developing embryos and adult tissues of 3 new members of the mouse Zfp. All of them are expressed as multiple transcripts. Unaltered level of mkr5 expression could be detected in 10-15 day whole embryo RNAs but its level started to decrease from day 16. In the adult animal, predominant expression was detected only in the ovary. In contrast, mkr3 and 4 were expressed at a constant level in all embryos and tissues tested. These data suggest the presence of both tissue specific and ubiquitious Zfp in the mouse.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Southern Cloning, Molecular DNA-Binding Proteins/genetics Embryo, Mammalian Genes Metalloproteins/genetics Mice Mice, Inbred C57BL Molecular Sequence Data Transcription, Genetic Zinc/metabolism
Chemicals
DNA-Binding Proteins Metalloproteins Zinc
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chowdhury K
Max-Planck Institute for Biophysical Chemistry, Göttingen, FRG.
Rohdewohld H
Gruss P
References (37)
37 references, click to expand
  1. A new method for sequencing DNA.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 PMID: 265521
  2. Homoeo box genes of the mouse.
    Oxf Surv Eukaryot Genes. 1987;4:92-115 PMID: 2908024
  3. Mutations affecting segment number and polarity in Drosophila.
    Nature. 1980 Oct 30;287(5785):795-801 PMID: 6776413
  4. Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene.
    J Biol Chem. 1983 Dec 10;258(23):14120-5 PMID: 6196359
  5. Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development.
    Cell. 1984 Dec;39(3 Pt 2):479-89 PMID: 6210149
  6. A short amino acid sequence able to specify nuclear location.
    Cell. 1984 Dec;39(3 Pt 2):499-509 PMID: 6096007
  7. The primary structure of transcription factor TFIIIA has 12 consecutive repeats.
    FEBS Lett. 1985 Jul 8;186(2):271-4 PMID: 4007166
  8. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.
    EMBO J. 1985 Jun;4(6):1609-14 PMID: 4040853
  9. Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene.
    J Mol Biol. 1985 Nov 5;186(1):149-66 PMID: 3935797
  10. The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity.
    Nature. 1985 Dec 19-1986 Jan 1;318(6047):630-5 PMID: 4079979
  11. Sequence homology of the yeast regulatory protein ADR1 with Xenopus transcription factor TFIIIA.
    Nature. 1986 Mar 20-26;320(6059):283-7 PMID: 3515197
  12. Potential metal-binding domains in nucleic acid binding proteins.
    Science. 1986 Apr 25;232(4749):485-7 PMID: 2421409
  13. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
    Cell. 1986 Aug 29;46(5):659-67 PMID: 3488815
  14. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene.
    Cell. 1986 Dec 26;47(6):1025-32 PMID: 3096579
  15. EXAFS study of the zinc-binding sites in the protein transcription factor IIIA.
    Nature. 1986 Dec 18-31;324(6098):698-9 PMID: 3796733
  16. Homeotic genes and the homeobox.
    Annu Rev Genet. 1986;20:147-73 PMID: 2880555
  17. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes.
    Cell. 1987 Mar 13;48(5):771-8 PMID: 3815523
  18. Metal-dependent folding of a single zinc finger from transcription factor IIIA.
    Proc Natl Acad Sci U S A. 1987 Jul;84(14):4841-5 PMID: 3474629
  19. Two zinc fingers of a yeast regulatory protein shown by genetic evidence to be essential for its function.
    Nature. 1987 Jul 30-Aug 5;328(6129):443-5 PMID: 3112579
  20. Drosophila Krüppel gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA.
    Proc Natl Acad Sci U S A. 1987 Aug;84(16):5700-4 PMID: 3112773
  21. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain.
    Cell. 1987 Dec 24;51(6):1079-90 PMID: 3319186
  22. The sex-determining region of the human Y chromosome encodes a finger protein.
    Cell. 1987 Dec 24;51(6):1091-104 PMID: 3690661
  23. Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.
    Proc Natl Acad Sci U S A. 1988 Jan;85(1):99-102 PMID: 3124104
  24. Zinc fingers: gilt by association.
    Cell. 1988 Jan 15;52(1):1-3 PMID: 3125980
  25. Disruption of a putative Cys-zinc interaction eliminates the biological activity of the Krüppel finger protein.
    Nature. 1988 Mar 3;332(6159):90-2 PMID: 3126398
  26. Tat protein from human immunodeficiency virus forms a metal-linked dimer.
    Science. 1988 Apr 1;240(4848):70-3 PMID: 2832944
  27. Divergent homeo box proteins recognize similar DNA sequences in Drosophila.
    Nature. 1988 Apr 28;332(6167):858-61 PMID: 2895896
  28. A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells.
    EMBO J. 1988 Jan;7(1):29-35 PMID: 3129290
  29. The molecular basis for metameric pattern in the Drosophila embryo.
    Development. 1987 Sep;101(1):1-22 PMID: 2896587
  30. Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene.
    EMBO J. 1988 Feb;7(2):485-94 PMID: 3284746
  31. Characterization of a mouse multigene family that encodes zinc finger structures.
    Mol Cell Biol. 1988 Mar;8(3):1319-26 PMID: 2452975
  32. Fingering too many proteins.
    Cell. 1988 Jun 3;53(5):675 PMID: 3370671
  33. Mapping functional regions of transcription factor TFIIIA.
    Mol Cell Biol. 1988 Apr;8(4):1684-96 PMID: 2837652
  34. Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.
    Mol Cell Biol. 1988 Apr;8(4):1853-6 PMID: 3380101
  35. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation.
    Nucleic Acids Res. 1988 May 25;16(10):4227-37 PMID: 3380682
  36. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons.
    EMBO J. 1988 May;7(5):1345-53 PMID: 3409867
  37. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
    Biochemistry. 1979 Nov 27;18(24):5294-9 PMID: 518835
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/16.21.9995
Published
1988-11-11
Pages
9995-10011
Language
English
Region
England
NLM ID
0411011
PMCID
PMC338832
Subset
IM
Databases
GENBANK
X12592, X12593, X12594
External Links
PubMed source DOI: 10.1093/nar/16.21.9995 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2