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PMID: 3149584 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.

The EMBO journal ·Vol. 7 ·No. 13 ·1988-12-20 ·Pages 4265-73

Perkins KK, Dailey GM, Tjian R

Abstract

A homolog of mammalian enhancer binding factor AP-1 was detected in Drosophila and was purified from embryo nuclear extracts by sequence-specific DNA affinity chromatography. The purified fraction, dAP-1, displays the sequence specificity as well as transcriptional activation properties of mammalian AP-1 and consists of two major proteins of mol. wts 40 and 70 kd. Antibody cross-reactivity experiments suggest that these proteins are Drosophila homologs of proto-oncogene products, Jun and Fos. The Drosophila Jun- and Fos-related antigens, when separated, are individually capable of sequence-specific DNA binding, and the Jun-related antigen activates transcription in vitro.

MeSH Terms
Animals Antigens/genetics,isolation & purification Binding Sites Biological Evolution DNA/metabolism DNA-Binding Proteins/genetics,immunology,isolation & purification Drosophila/genetics,immunology,metabolism Humans Molecular Weight Proto-Oncogene Mas Proto-Oncogene Proteins/genetics,isolation & purification Proto-Oncogene Proteins c-jun Species Specificity Transcription Factors/genetics,immunology,isolation & purification Transcription, Genetic
Chemicals
Antigens DNA-Binding Proteins MAS1 protein, human Proto-Oncogene Mas Proto-Oncogene Proteins Proto-Oncogene Proteins c-jun Transcription Factors DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Perkins K K
Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley, CA 94720.
Dailey G M
Tjian R
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-12-20
Pages
4265-73
Language
English
Region
England
NLM ID
8208664
PMCID
PMC455140
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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