Therapeutic efficacy of teicoplanin in experimental enterococcal endocarditis.

Antimicrobial agents and chemotherapy ·Vol. 27 ·No. 1 ·1985-01-00 ·Pages 135-6

Sullam PM, Täuber MG, Hackbarth CJ, Sande MA

Abstract

The antimicrobial activities of teicoplanin and ampicillin, alone and in combination with gentamicin, were compared in experimental Streptococcus faecalis endocarditis. Bacterial titers in vegetations of rabbits treated with teicoplanin were significantly lower than those of untreated controls (P less than 0.01) and were equivalent to titers in ampicillin-treated animals. Gentamicin increased the activities of both drugs to a comparable degree.

MeSH Terms

Ampicillin/pharmacology Animals Anti-Bacterial Agents/therapeutic use Endocarditis, Bacterial/drug therapy,microbiology Enterococcus faecalis/drug effects Gentamicins/pharmacology Glycopeptides/therapeutic use Microbial Sensitivity Tests Rabbits Streptococcal Infections/drug therapy Teicoplanin Time Factors

Chemicals

Anti-Bacterial Agents Gentamicins Glycopeptides Teicoplanin Ampicillin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Sullam P M

Täuber M G

Hackbarth C J

Sande M A

References (8)

8 references, click to expand

Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart.
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Simple method for elimination of aminoglycosides from serum to permit bioassay of other antimicrobial agents.
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Resistance to six aminoglycosidic aminocyclitol antibiotics among enterococci: prevalence, evolution, and relationship to synergism with penicillin.
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Species-specific resistance to antimocrobial synergism in Streptococcus faecium and Streptococcus faecalis.
J Infect Dis. 1979 Aug;140(2):203-8 PMID: 113469
A novel mechanism of resistance to penicillin-gentamicin synergism in Streptococcus faecalis.
J Infect Dis. 1980 Jan;141(1):81-6 PMID: 6767791
Comparison of the in vitro activities of teichomycin A2 and vancomycin against staphylococci and enterococci.
Antimicrob Agents Chemother. 1982 Mar;21(3):504-5 PMID: 6213192
High-level resistance to gentamicin in clinical isolates of enterococci.
J Infect Dis. 1983 Apr;147(4):751-7 PMID: 6404994
Comparative in vitro activities of teichomycin and vancomycin alone and in combination with rifampin and aminoglycosides against staphylococci and enterococci.
Antimicrob Agents Chemother. 1984 Apr;25(4):411-2 PMID: 6233934

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.27.1.135

Published

1985-01-00

Pages

135-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC176220

Subset

External Links

PubMed source DOI: 10.1128/AAC.27.1.135 PMC Full Text View journal details

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Therapeutic efficacy of teicoplanin in experimental enterococcal endocarditis.

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