Plasmid-mediated chloramphenicol resistance in Haemophilus influenzae.

Antimicrobial agents and chemotherapy ·Vol. 11 ·No. 3 ·1977-03-00 ·Pages 383-7

van Klingeren B, van Embden JD, Dessens-Kroon M

Abstract

A clinical isolate of Haemophilus influenzae HC234 was found to be resistant to chloramphenicol and tetracycline. It was shown that both resistance markers are tranferable as one unit to other Haemophilus influenzae strains and also to Escherichia coli. Data are presented which indicate that conjugation is the most likely mechanism of resistance transfer. HC234 was shown to carry a single plasmid species with a molecular weight of 38 x 10(6).

MeSH Terms

Chloramphenicol/pharmacology Conjugation, Genetic DNA, Bacterial/isolation & purification Drug Resistance, Microbial Escherichia coli/drug effects,isolation & purification Extrachromosomal Inheritance Haemophilus influenzae/analysis,drug effects Kinetics Microbial Sensitivity Tests Plasmids Tetracycline/pharmacology

Chemicals

DNA, Bacterial Chloramphenicol Tetracycline

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

van Klingeren B

van Embden J D

Dessens-Kroon M

References (15)

15 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.11.3.383

Published

1977-03-00

Pages

383-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC351993

Subset

External Links

PubMed source DOI: 10.1128/AAC.11.3.383 PMC Full Text View journal details

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Plasmid-mediated chloramphenicol resistance in Haemophilus influenzae.

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