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PMID: 3258004 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A large subpopulation of avian T cells express a homologue of the mammalian T gamma/delta receptor.

The Journal of experimental medicine ·Vol. 167 ·No. 2 ·1988-02-01 ·Pages 315-22

Sowder JT, Chen CL, Ager LL, Chan MM, Cooper MD

Abstract

This report describes an avian TCR molecule, TCR1, whose molecular characteristics, signal-transducing property, and tissue distribution suggest that it is a homologue of the mammalian TCR-gamma/delta. TCR1+ cells are the first to be generated in the thymus during ontogeny, preceding other T3+ cells by approximately 3 d. Unlike their mammalian counterpart, TCR1+ cells constitute a relatively large subpopulation of peripheral T cells in mature chickens. These results suggest a phylogenetically important role for this receptor in T cell development and function.

MeSH Terms
Animals Antigens, Differentiation, T-Lymphocyte/analysis,immunology Cell Differentiation Chick Embryo Chickens/growth & development,immunology Lymphocyte Activation Mice Mice, Inbred BALB C Phenotype Receptors, Antigen, T-Cell/analysis,immunology,isolation & purification T-Lymphocytes/analysis,classification,metabolism Tissue Distribution
Chemicals
Antigens, Differentiation, T-Lymphocyte Receptors, Antigen, T-Cell
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sowder J T
Cellular Immunobiology Unit, University of Alabama, Birmingham 35294.
Chen C L
Ager L L
Chan M M
Cooper M D
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.167.2.315
Published
1988-02-01
Pages
315-22
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2188863
Subset
IM
Grants
NCI NIH HHS · CA 09128 · United States
NCI NIH HHS · CA 13148 · United States
NCI NIH HHS · CA 16673 · United States
External Links
PubMed source DOI: 10.1084/jem.167.2.315 PMC Full Text View journal details
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