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PMID: 3262629 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells.

The Journal of clinical investigation ·Vol. 82 ·No. 4 ·1988-10-00 ·Pages 1466-70

Dejana E, Bertocchi F, Bortolami MC, Regonesi A, Tonta A, Breviario F, Giavazzi R

Abstract

We report that IL 1 acts on the endothelium, inducing a long-lasting increase in its adhesivity to tumor cells. Selective pretreatment of cultured human umbilical vein endothelial cells (EC) with IL 1 caused a significant increase in adhesion of three human colorectal carcinoma (HT-29, HCC-P2988, and HCC-M1410) cell lines and one human melanoma (A-375) cell line. Tumor necrosis factor (TNF) was as effective as IL 1 in promoting tumor cell adhesion to EC, whereas IFN gamma and IL 2 were inactive. The IL 1 and TNF induction of EC adhesivity was both concentration (threshold concentration 1 U/ml) and time dependent (peak 4-6 h), reversible within 24 h, and blocked by a protein synthesis inhibitor. The IL 1 and TNF action on EC may play a role in tumor cell lodgement.

MeSH Terms
Animals Cell Adhesion/drug effects Cell Line Endothelium, Vascular/drug effects,ultrastructure Humans Interleukin-1/pharmacology Kinetics Mice Mice, Nude Tumor Cells, Cultured/drug effects,pathology,ultrastructure Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Interleukin-1 Tumor Necrosis Factor-alpha
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Dejana E
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Bertocchi F
Bortolami M C
Regonesi A
Tonta A
Breviario F
Giavazzi R
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI113753
Published
1988-10-00
Pages
1466-70
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC442706
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI113753 PMC Full Text View journal details
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