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PMID: 3275436 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus.

Journal of virology ·Vol. 62 ·No. 1 ·1988-01-00 ·Pages 354-6

Glickman RL, Syddall RJ, Iorio RM, Sheehan JP, Bratt MA

Abstract

Newcastle disease virus exhibits a wide range of pathogenicity and virulence which, as with all paramyxoviruses, is directly related to the cleavability of a precursor (F0) of the fusion glycoprotein by cellular proteases. Sequence analyses of the cleavage site of several virulent and avirulent isolates of the Newcastle disease virus serotype reveal a correlation between virulence or pathogenicity and a high content of basic amino acid residues at the cleavage site. A similar correlation has been seen for other paramyxoviruses.

MeSH Terms
Amino Acid Sequence Newcastle disease virus/metabolism,pathogenicity Peptide Hydrolases/metabolism Protein Precursors/metabolism Structure-Activity Relationship Viral Fusion Proteins/metabolism
Chemicals
Protein Precursors Viral Fusion Proteins Peptide Hydrolases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Glickman R L
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605.
Syddall R J
Iorio R M
Sheehan J P
Bratt M A
References (19)
19 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.62.1.354-356.1988
Published
1988-01-00
Pages
354-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC250538
Subset
IM
Grants
NIAID NIH HHS · AI-12467-11 · United States
NIAID NIH HHS · AI-20762-03 · United States
External Links
PubMed source DOI: 10.1128/JVI.62.1.354-356.1988 PMC Full Text View journal details
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