Nocardia water-soluble mitogen and lipopolysaccharide. Comparative study of two adjuvants and B-cell mitogens in mice.

Immunology ·Vol. 32 ·No. 6 ·1977-06-00 ·Pages 975-80

Lowy I, Bona C, Ciorbaru R, Chedid L

Abstract

The activity of Nocardia water-soluble mitogen (NWSM) and LPS were compared in several experimental systems, since both compounds are B-cell mitogens and polyclonal activators in vitro. The results reported here demonstrated that NWSM like LPS also has a strong adjuvant activity in vivo if administered in saline with a strong antigen (heterologous red blood cells) or even with a weak immunogen such as theta alloantigen. However, in contrast to LPS, NWSM administered to mice failed to induce in vivo proliferation of lymphocytes, polyclonal activation and PFC against syngeneic bromelain-treated erythrocytes and thymocytes. It is possible therefore, that different mechanisms may be responsible for adjuvant activity of NWSM and LPS.

MeSH Terms

Adjuvants, Immunologic Animals Antibody-Producing Cells Bromelains Erythrocytes/immunology Female Hemolytic Plaque Technique Isoantibodies/analysis Isoantigens Lipopolysaccharides/immunology Mice Mitogens Nocardia/immunology T-Lymphocytes/immunology

Chemicals

Adjuvants, Immunologic Isoantibodies Isoantigens Lipopolysaccharides Mitogens Bromelains

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lowy I

Bona C

Ciorbaru R

Chedid L

References (13)

13 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1977-06-00

Pages

975-80

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1445450

Subset

External Links

PubMed source PMC Full Text View journal details

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Nocardia water-soluble mitogen and lipopolysaccharide. Comparative study of two adjuvants and B-cell mitogens in mice.

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