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PMID: 3294576 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sialadenitis in the MRL-l mouse: morphological and immunohistochemical characterization of resident and infiltrating cells.

Immunology ·Vol. 60 ·No. 4 ·1987-04-00 ·Pages 611-6

Jonsson R, Tarkowski A, Bäckman K, Holmdahl R, Klareskog L

Abstract

The MRL-lpr/lpr (MRL/l) mouse spontaneously develops an autoimmune disease associated with various rheumatic manifestations. We have studied the histological features of sialadenitis and utilized an immunohistochemical staining technique on frozen tissue sections to analyse the cellular composition of the salivary glands at varying stages of disease. Semiquantitative assessment of the infiltration disclosed a focal inflammation which started at 2 months of age and was progressive until 5 months of age in submandibular glands. A high frequency of Ly-1 and L3T4-positive cells was observed at all stages of sialadenitis, whereas Lyt-2 positive cells were found at a lower frequency. Ia expression was seen on a large proportion of the infiltrating cells and also on ductal and glandular epithelial cells in the vicinity of the inflammatory lesions. The presence of Ia antigens on many inflammatory as well as resident cells and the high frequency of lymphocytes with 'helper' phenotype may indicate a perpetuated immunological activation within salivary glands.

MeSH Terms
Animals Autoimmune Diseases/immunology Female Immunoenzyme Techniques Lymph Nodes/immunology Lymphocytes/classification Mice Mice, Inbred Strains Salivary Gland Diseases/immunology Salivary Glands/immunology,pathology Sialadenitis/immunology,pathology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Jonsson R
Tarkowski A
Bäckman K
Holmdahl R
Klareskog L
References (29)
29 references, click to expand
  1. The histopathology of Sjögren's syndrome in labial salivary gland biopsies.
    Oral Surg Oral Med Oral Pathol. 1974 Feb;37(2):217-29 PMID: 4589360
  2. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.
    J Exp Med. 1978 Nov 1;148(5):1198-215 PMID: 309911
  3. Distribution of lymphocytes identified by surface markers in murine strains with systemic lupus erythematosus-like syndromes.
    J Exp Med. 1979 Feb 1;149(2):516-34 PMID: 762500
  4. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody.
    Eur J Immunol. 1979 Apr;9(4):301-6 PMID: 89034
  5. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.
    Immunol Rev. 1979;47:63-90 PMID: 398327
  6. Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice.
    Nature. 1981 Jan 22;289(5795):298-300 PMID: 6969857
  7. Etiopathogenesis of murine SLE.
    Immunol Rev. 1981;55:179-216 PMID: 6165672
  8. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
    J Histochem Cytochem. 1981 Apr;29(4):577-80 PMID: 6166661
  9. Antigens displayed on murine B lymphocyte precursors.
    J Immunol. 1981 Dec;127(6):2262-8 PMID: 6975314
  10. Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in Sjögren's syndrome.
    Arthritis Rheum. 1982 Apr;25(4):419-26 PMID: 6978718
  11. A spontaneous rheumatoid arthritis-like disease in MRL/l mice.
    J Exp Med. 1982 Jun 1;155(6):1690-701 PMID: 7077223
  12. Murine synovial intima contains I-A-, I-E/C-positive bone-marrow-derived cells.
    Scand J Immunol. 1981 May;15(5):509-14 PMID: 7048511
  13. Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.
    J Immunol. 1982 Dec;129(6):2612-5 PMID: 6815273
  14. Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.
    J Exp Med. 1983 Feb 1;157(2):730-42 PMID: 6600490
  15. Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.
    Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8 PMID: 6412230
  16. Immunocompetent cells in labial salivary glands in secondary Sjögren's syndrome associated with SLE.
    J Oral Pathol. 1983 Dec;12(6):465-72 PMID: 6418868
  17. Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases.
    Arthritis Rheum. 1984 Feb;27(2):147-56 PMID: 6696772
  18. Sjögren's syndrome in MRL/l and MRL/n mice.
    Arthritis Rheum. 1984 Feb;27(2):157-65 PMID: 6421291
  19. Autoreactivity to collagen in a murine lupus model.
    Arthritis Rheum. 1984 Mar;27(3):313-9 PMID: 6608354
  20. The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.
    J Immunol. 1984 Jun;132(6):2686-9 PMID: 6144707
  21. A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.
    J Immunol. 1984 Jun;132(6):2775-82 PMID: 6202760
  22. An immunohistological study of secondary Sjögren's syndrome.
    Ann Rheum Dis. 1984 Jun;43(3):470-6 PMID: 6378107
  23. Detection of IgG rheumatoid factor secreting cells in autoimmune MRL/1 mice: a kinetic study.
    Clin Exp Immunol. 1984 Oct;58(1):7-12 PMID: 6383669
  24. Quantitative studies on T-cell functions in MRL/MP-Lpr/Lpr mice. I. Frequency analysis of precursor cells of proliferating, cytotoxic, and T-cell growth factor-secreting T lymphocytes reveals an increase in absolute numbers, with a concomitant decrease in percentage of immunocompetent cells.
    Clin Immunol Immunopathol. 1984 Oct;33(1):39-53 PMID: 6332698
  25. In vivo treatment of rats with monoclonal anti-T-cell antibodies. Immunohistochemical and functional analysis in normal rats and in experimental allergic neuritis.
    Scand J Immunol. 1985 Aug;22(2):157-69 PMID: 3898352
  26. Epithelial HLA-DR expression and T lymphocyte subsets in salivary glands in Sjögren's syndrome.
    Clin Exp Immunol. 1985 Sep;61(3):475-82 PMID: 3907899
  27. Patterns of autoreactivity to collagen type II in autoimmune MRL/l mice.
    Clin Exp Immunol. 1986 Feb;63(2):441-9 PMID: 3516469
  28. Immunohistochemical characterization of sialadenitis in NZB X NZW F1 mice.
    Clin Immunol Immunopathol. 1987 Jan;42(1):93-101 PMID: 3791713
  29. A clinicopathologic study of Mikulicz's disease.
    Am J Pathol. 1953 May-Jun;29(3):471-503 PMID: 13040489
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1987-04-00
Pages
611-6
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1453282
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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