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PMID: 7077223 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

The Journal of experimental medicine ·Vol. 155 ·No. 6 ·1982-06-01 ·Pages 1690-701

Hang L, Theofilopoulos AN, Dixon FJ

Abstract

MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.

MeSH Terms
Aging Animals Antigen-Antibody Complex Arthritis, Rheumatoid/immunology,pathology Autoantibodies/biosynthesis Female Immunoglobulin M/biosynthesis Lymphocytes/ultrastructure Macrophages/ultrastructure Male Mice Mice, Inbred C57BL Mice, Inbred NZB Mice, Inbred Strains Plasma Cells/ultrastructure Rheumatoid Factor/immunology
Chemicals
Antigen-Antibody Complex Autoantibodies Immunoglobulin M Rheumatoid Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hang L
Theofilopoulos A N
Dixon F J
References (29)
29 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.155.6.1690
Published
1982-06-01
Pages
1690-701
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186697
Subset
IM
Grants
NIA NIH HHS · AG-01743 · United States
NIAID NIH HHS · AI-07007 · United States
NCI NIH HHS · CA-27489 · United States
External Links
PubMed source DOI: 10.1084/jem.155.6.1690 PMC Full Text View journal details
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