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PMID: 3297370 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Cell-contact and -architecture of malignant cells and their relationship to metastasis.

Cancer metastasis reviews ·Vol. 6 ·No. 1 ·1987-00-00 ·Pages 3-21

Raz A, Ben-Ze'ev A

Abstract

The interaction of metastatic cells with the host environment occurs, to a large extent, through the cell surface, and the cell cytoskeletal system controls the distribution and motility of cell surface receptors. During metastasis, tumor cells migrate from one organ to another, and the dynamic properties and mechanochemical deformability of disseminated cells play a central role in the process. The studies described here under suggest an interrelationship between the cytoskeleton and cell adhesion, which can control and augment the expression of the metastatic phenotype of neoplastic cells.

MeSH Terms
Actins/analysis Animals Cell Adhesion Cell Communication Cell Movement Cytoskeleton/analysis Intermediate Filaments/ultrastructure Neoplasm Metastasis Neoplasms, Experimental/pathology Phenotype
Chemicals
Actins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Raz A
Ben-Ze'ev A
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76 references, click to expand
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00047606
Published
1987-00-00
Pages
3-21
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · 7RO/CA3942202 · United States
External Links
PubMed source DOI: 10.1007/BF00047606 View journal details
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