Home LiteratureArticle Details
PMID: 3301528 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chromosome specificity of polysomy promotion by disruptions of the Saccharomyces cerevisiae RNA1 gene.

Genetics ·Vol. 116 ·No. 3 ·1987-07-00 ·Pages 371-5

Atkinson NS, Hopper AK

Abstract

Previously, we showed that a disruption of the yeast RNA1 gene with LEU2 sequences promotes polysomy for chromosome XIII. Here we demonstrate that this phenotype is due to sequences specific to the RNA1 gene and that the disruption allele does not affect nondisjunction of three other chromosomes or polysomy of a minichromosome. Hence polysomy appears to be restricted to chromosome XIII.

MeSH Terms
Aneuploidy DNA, Fungal/genetics Gene Amplification Genes, Fungal Genotype Leucine/genetics Mitosis RNA, Fungal/genetics Saccharomyces cerevisiae/genetics Transcription, Genetic
Chemicals
DNA, Fungal RNA, Fungal Leucine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Atkinson N S
Hopper A K
References (8)
8 references, click to expand
  1. Temperature-sensitive yeast mutant defective in ribonucleic acid production.
    J Bacteriol. 1969 Sep;99(3):807-14 PMID: 5370278
  2. A yeast mutant which accumulates precursor tRNAs.
    Cell. 1978 Jun;14(2):211-9 PMID: 352536
  3. The organization and transcription of the galactose gene cluster of Saccharomyces.
    J Mol Biol. 1981 Oct 25;152(2):285-315 PMID: 6276569
  4. Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins.
    Mol Cell Biol. 1986 Nov;6(11):3722-33 PMID: 3540600
  5. One-step gene disruption in yeast.
    Methods Enzymol. 1983;101:202-11 PMID: 6310324
  6. Transfer of yeast telomeres to linear plasmids by recombination.
    Cell. 1984 Nov;39(1):191-201 PMID: 6091911
  7. Characterization of an essential Saccharomyces cerevisiae gene related to RNA processing: cloning of RNA1 and generation of a new allele with a novel phenotype.
    Mol Cell Biol. 1985 May;5(5):907-15 PMID: 3889591
  8. Isolation of the yeast regulatory gene GAL4 and analysis of its dosage effects on the galactose/melibiose regulon.
    Proc Natl Acad Sci U S A. 1982 Nov;79(22):6971-5 PMID: 6294669
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/116.3.371
Published
1987-07-00
Pages
371-5
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1203148
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/116.3.371 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2