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PMID: 3325828 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

Molecular and cellular biology ·Vol. 7 ·No. 12 ·1987-12-00 ·Pages 4564-7

Schleuning WD, Medcalf RL, Hession C, Rothenbühler R, Shaw A, Kruithof EK

Abstract

We have isolated and sequenced two cDNA clones coding for plasminogen activator inhibitor 2 (PAI-2). The cDNA was used to study the regulation of PAI-2 gene transcription by the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate in the human histiocytic lymphoma cell line U-937. The tumor promoter caused a transient, 50-fold increase of PAI-2 gene transcription.

MeSH Terms
Base Sequence Cell Differentiation/drug effects DNA/genetics DNA, Recombinant Escherichia coli/genetics Glycoproteins/genetics Humans Lymphoma, Large B-Cell, Diffuse/metabolism,pathology Molecular Sequence Data Plasmids Plasminogen Inactivators RNA, Messenger/biosynthesis Templates, Genetic Tetradecanoylphorbol Acetate/pharmacology Transcription, Genetic/drug effects Transformation, Genetic Tumor Cells, Cultured
Chemicals
DNA, Recombinant Glycoproteins Plasminogen Inactivators RNA, Messenger DNA Tetradecanoylphorbol Acetate
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Schleuning W D
Department of Medicine, University Hospital Center, CHUV, Lausanne, Switzerland.
Medcalf R L
Hession C
Rothenbühler R
Shaw A
Kruithof E K
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.12.4564-4567.1987
Published
1987-12-00
Pages
4564-7
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368144
Subset
IM
Databases
GENBANK
M18082
External Links
PubMed source DOI: 10.1128/mcb.7.12.4564-4567.1987 PMC Full Text View journal details
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