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PMID: 334064 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Plasmids carried by antibiotic-resistant marine bacteria.

Antimicrobial agents and chemotherapy ·Vol. 12 ·No. 3 ·1977-09-00 ·Pages 373-82

Sizemore RK, Colwell RR

Abstract

Antibiotic-resistant bacteria were isolated from seawater samples collected in the Atlantic Ocean off the southeastern coast of the United States. Large numbers of antibiotic-resistant bacterial strains were found to be present in harbor and inshore waters; however, the percentage of resistant strains was higher for several seawater samples collected offshore than for those collected near shore. Bacteria resistant to tetracycline, chloramphenicol, and streptomycin were found in nearly all samples collected, including samples from 200 miles (about 522 km) offshore and at depths to 8,200 m. Sediment samples, in general, were found to contain smaller populations of resistant strains as compared with the seawater samples examined. Antibiotic-resistant bacteria exhibiting phenetic characteristics common to autochthonous marine bacterial species were examined in detail, and several of the isolates exhibited unstable antibiotic resistance, which was transferable to recipient Escherichia coli cells. Deoxyribonucleic acid preparations from 10 strains examined by ethidium bromide-cesium chloride density sedimentation revealed that 6 of the strains contained covalently closed circular plasmid deoxyribonucleic acid.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacteria/drug effects,genetics DNA, Bacterial DNA, Circular Escherichia coli/drug effects R Factors Seawater Transformation, Bacterial Water Microbiology
Chemicals
Anti-Bacterial Agents DNA, Bacterial DNA, Circular
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sizemore R K
Colwell R R
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18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.12.3.373
Published
1977-09-00
Pages
373-82
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC429921
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.12.3.373 PMC Full Text View journal details
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