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PMID: 3348948 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Structure and expression of c-myc and c-fos proto-oncogenes in thyroid carcinomas.

British journal of cancer ·Vol. 57 ·No. 1 ·1988-01-00 ·Pages 43-7

Terrier P, Sheng ZM, Schlumberger M, Tubiana M, Caillou B, Travagli JP, Fragu P, Parmentier C, Riou G

Abstract

Tumour specimens from 23 patients with thyroid carcinoma, 22 patients with thyroid adenoma, 3 with Graves' disease, and tissues from 8 normal thyroid glands were analyzed by Southern blot hybridization for the physical state of c-myc and c-fos proto-oncogenes. In 4 patients, both the primary tumour and lymph node metastases were analyzed. No amplification or rearrangement of the two proto-oncogenes was detected. Total RNAs were also analyzed. Elevated levels of the 2.4 kb c-myc RNA and of the 2.2 kb c-fos RNA were found in 13/23 (57%) and 14/23 (61%) of the cancer patients, respectively. High levels of c-myc transcripts were more frequently found in thyroid carcinomas with unfavourable prognosis. Concomitant elevated levels of both c-myc and c-fos RNAs were found in 8 cancers. High levels of c-myc RNA were also found in 1 out of 22 specimens of adenoma, in 1 specimen of Graves' disease and in 2 normal thyroid glands. High levels of c-fos RNA were found in 20 of the 22 adenoma samples and in 2 out of 8 normal thyroid tissues. These data indicate that the overexpression of c-myc and c-fos genes is independent of an alteration of the loci. The high levels of c-fos found in adenoma may be associated with the differentiation state of these tumours.

MeSH Terms
Adenoma/genetics Adolescent Adult Aged Carcinoma/genetics Cell Transformation, Neoplastic Child Electrophoresis, Agar Gel Female Gene Amplification Graves Disease/genetics Humans Lymph Nodes/analysis Lymphatic Metastasis Male Middle Aged Prognosis Proto-Oncogenes RNA, Neoplasm/analysis Thyroid Neoplasms/genetics Transcription, Genetic
Chemicals
RNA, Neoplasm
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Terrier P
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy, Villejuif, France.
Sheng Z M
Schlumberger M
Tubiana M
Caillou B
Travagli J P
Fragu P
Parmentier C
Riou G
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1988.6
Published
1988-01-00
Pages
43-7
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2246694
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1988.6 PMC Full Text View journal details
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