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PMID: 336598 Published · ppublish English Journal Article

Effects of a protease inhibitor on biosynthesis of Escherichia coli proteins.

Journal of bacteriology ·Vol. 132 ·No. 3 ·1977-12-00 ·Pages 1021-3

Ito K

Abstract

A protease inhibitor, tosyl-L-lysine chloromethylketone, altered the composition of newly synthesized protein in Escherichia coli; a significant portion of the proteins synthesized sedimented rapidly, presumably forming aggregates of the abnormal proteins. Protein I of the outer membrane was only slightly synthesized under these conditions.

MeSH Terms
Amino Acid Chloromethyl Ketones/pharmacology Bacterial Proteins/analysis,biosynthesis Centrifugation Escherichia coli/drug effects,metabolism Membrane Proteins/analysis,biosynthesis Tosyllysine Chloromethyl Ketone/pharmacology
Chemicals
Amino Acid Chloromethyl Ketones Bacterial Proteins Membrane Proteins Tosyllysine Chloromethyl Ketone
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ito K
References (10)
10 references, click to expand
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    J Biol Chem. 1972 May 25;247(10):3341-52 PMID: 4554917
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    J Biol Chem. 1974 Jun 10;249(11):3412-7 PMID: 4364655
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    J Biol Chem. 1975 Oct 10;250(19):7771-9 PMID: 240839
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    J Biol Chem. 1975 Feb 10;250(3):1112-22 PMID: 1089651
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.132.3.1021-1023.1977
Published
1977-12-00
Pages
1021-3
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235604
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.132.3.1021-1023.1977 PMC Full Text View journal details
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