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PMID: 3395107 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant Pseudomonas maltophilia.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 5 ·1988-05-00 ·Pages 782-4

Chow AW, Wong J, Bartlett KH

Abstract

The susceptibility of 28 clinical isolates of Pseudomonas maltophilia to 16 antimicrobial agents was determined in vitro by a standard agar dilution method with inoculum sizes of 10(4) and 10(6) CFU. All isolates exhibited multiple drug resistance. Nine isolates were selected for studies of combinations of ciprofloxacin with seven antipseudomonal beta-lactams and three aminoglycosides by a checkerboard agar dilution technique. Synergistic or additive combinations of ciprofloxacin in clinically achievable concentrations were most frequent with mezlocillin (89%), followed by cefoperazone (67%), piperacillin (56%), cefsulodin (56%), and ceftazidime (33%), and were infrequent with aztreonam (11%), the aminoglycosides (0 to 14%), or imipenem (0%). Antagonism was not observed in any combination. These data suggest that combinations of ciprofloxacin with these agents may be useful for some nosocomial multiply drug-resistant P. maltophilia infections.

MeSH Terms
Aminoglycosides Anti-Bacterial Agents/pharmacology Ciprofloxacin/pharmacology Drug Resistance, Microbial Drug Synergism Humans Microbial Sensitivity Tests Pseudomonas/drug effects beta-Lactams
Chemicals
Aminoglycosides Anti-Bacterial Agents beta-Lactams Ciprofloxacin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chow A W
Department of Medicine, University of British Columbia, Vancouver, Canada.
Wong J
Bartlett K H
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16 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.32.5.782
Published
1988-05-00
Pages
782-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172276
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.32.5.782 PMC Full Text View journal details
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