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PMID: 3414687 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

5-Aminolevulinate synthase is at 3p21 and thus not the primary defect in X-linked sideroblastic anemia.

American journal of human genetics ·Vol. 43 ·No. 3 ·1988-09-00 ·Pages 331-5

Sutherland GR, Baker E, Callen DF, Hyland VJ, May BK, Bawden MJ, Healy HM, Borthwick IA

Abstract

The gene for 5-aminolevulinate synthase (ALAS) has been mapped to 3pter-3q13.2 by Southern blot hybridization analysis of a mouse/human hybrid cell panel. In situ hybridization maps the gene to 3p21, distal to the common fragile site at 3p14.2 (FRA3B). The mapping of this gene to an autosome makes it improbable that it is the site of the primary defect in X-linked sideroblastic anemia.

MeSH Terms
5-Aminolevulinate Synthetase/genetics Anemia, Sideroblastic/genetics Chromosome Mapping Chromosomes, Human, Pair 3 Cloning, Molecular Humans Nucleic Acid Hybridization
Chemicals
5-Aminolevulinate Synthetase
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Sutherland G R
Cytogenetics Unit, Adelaide Children's Hospital, Australia.
Baker E
Callen D F
Hyland V J
May B K
Bawden M J
Healy H M
Borthwick I A
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17 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1988-09-00
Pages
331-5
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1715374
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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