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PMID: 34505 Published · ppublish English Journal Article

Continuous peritoneal dialysis as treatment of acute experimental pancreatitis in the rat. II. Analysis of its beneficial effect.

Digestive diseases and sciences ·Vol. 24 ·No. 2 ·1979-02-00 ·Pages 117-22

Lankisch PG, Koop H, Winckler K, Schmidt H

Abstract

In acute sodium-taurocholate-induced pancreatitis in the rat, peritoneal dialysis reduced serum amylase levels and the amount of fat necrosis, but did not influence the damage to the pancreas itself. Pancreatic ascites obtained in the early course of the disease was found to have a hypotensive effect when given intraperitoneally to healthy rats. This effect vanished in the later course of acute experimental pancreatitis and was reduced by acidification of the ascites or by administration of an antihistaminic drug. Thus the beneficial effect of continuous peritoneal dialysis on survival time and mortality rate seems to be of systemic origin.

MeSH Terms
Acute Disease Amylases/blood Animals Antazoline/pharmacology Ascites/etiology,metabolism Ascitic Fluid/cytology,enzymology Blood Pressure Hydrogen-Ion Concentration Injections, Intraperitoneal Leukocyte Count Male Pancreatitis/complications,mortality,therapy Peritoneal Dialysis Phospholipases/metabolism Rats Taurocholic Acid Trypsin/metabolism Trypsinogen/metabolism
Chemicals
Taurocholic Acid Trypsinogen Antazoline Phospholipases Amylases Trypsin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lankisch P G
Koop H
Winckler K
Schmidt H
References (21)
21 references, click to expand
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Article Info
Journal
Digestive diseases and sciences
Abbr.
Dig Dis Sci
ISSN
0163-2116
DOI
10.1007/BF01324738
Published
1979-02-00
Pages
117-22
Language
English
Region
United States
NLM ID
7902782
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01324738 View journal details
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