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PMID: 3463975 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 19 ·1986-10-00 ·Pages 7400-4

Marth JD, Disteche C, Pravtcheva D, Ruddle F, Krebs EG, Perlmutter RM

Abstract

The murine lck gene is closely related to a family of cellular protooncogenes and encodes a lymphocyte-specific, membrane-associated protein tyrosine kinase. We and others have demonstrated that the lck gene is rearranged and overexpressed in the murine lymphoma LSTRA, most likely as a result of the insertion of Moloney murine leukemia virus DNA immediately adjacent to the gene. We now report that the lck gene is located at the distal end of murine chromosome 4 and on human chromosome 1 at position 1p32-35 near a site of frequent structural abnormalities in human lymphomas and neuroblastomas. These results raise the possibility that structural alteration of the lck gene through chromosomal rearrangement may contribute to transformation in human malignant disease.

MeSH Terms
Animals Chromosome Aberrations/genetics Chromosome Disorders Chromosome Mapping Chromosomes, Human, Pair 1 Humans Lymphocytes/enzymology Lymphoma/genetics Mice Multigene Family Nucleic Acid Hybridization Protein-Tyrosine Kinases/genetics
Chemicals
Protein-Tyrosine Kinases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Marth J D
Disteche C
Pravtcheva D
Ruddle F
Krebs E G
Perlmutter R M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.19.7400
Published
1986-10-00
Pages
7400-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC386725
Subset
IM
Grants
NIGMS NIH HHS · GM15253 · United States
NIGMS NIH HHS · GM30476 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.19.7400 PMC Full Text View journal details
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