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PMID: 3479750 Published · ppublish English Journal Article

Linkage of TNF genes to the HLA-B locus.

Nucleic acids research ·Vol. 15 ·No. 21 ·1987-11-11 ·Pages 8957-62

Inoko H, Trowsdale J

Abstract

Pulsed field gel electrophoresis was used to determine the location of the tumour necrosis factor (TNF) alpha and beta genes. They were shown to be linked to the HLA-B locus; analogous to their location in mouse, between the complement (class III) region and H-2D. However, the distance between the TNF genes and the class I region was much greater in man, namely about 260 kb, compared to 70 kb in the mouse. This finding may have implications for some HLA associated diseases.

MeSH Terms
Genes Genes, MHC Class I Genetic Linkage HLA Antigens/genetics HLA-B Antigens Humans Tumor Necrosis Factor-alpha/genetics
Chemicals
HLA Antigens HLA-B Antigens Tumor Necrosis Factor-alpha
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Inoko H
Human Immunogenetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Trowsdale J
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/15.21.8957
Published
1987-11-11
Pages
8957-62
Language
English
Region
England
NLM ID
0411011
PMCID
PMC306415
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/15.21.8957 PMC Full Text View journal details
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