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PMID: 3480534 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 24 ·1987-12-00 ·Pages 9145-9

Geraghty DE, Koller BH, Orr HT

Abstract

We have cloned genomic DNA encoding a non-HLA-A, -B, -C class I gene located within a HindIII-generated restriction fragment of 6.0 kilobase pairs. This gene, designated HLA-6.0, is as homologous to HLA-A and HLA-B as they are to each other. The HLA class I protein encoded by HLA-6.0 is similar in organization to the HLA-A-, -B-, and -C-encoded proteins except that an in-frame termination codon prevents translation of a majority of the cytoplasmic region of the HLA-6.0 polypeptide. Moreover, the promoter region of HLA-6.0 resembles the promoter region of a Qa region gene. These structural features of HLA-6.0 suggest that this non-HLA-A, -B, -C gene is a structural homolog of a murine Qa region class I gene.

MeSH Terms
Amino Acid Sequence Base Sequence Genes Genes, MHC Class I Humans Membrane Glycoproteins/genetics Molecular Sequence Data Multigene Family Promoter Regions, Genetic
Chemicals
Membrane Glycoproteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Geraghty D E
Institute of Human Genetics, University of Minnesota, Minneapolis 55455.
Koller B H
Orr H T
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.24.9145
Published
1987-12-00
Pages
9145-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC299709
Subset
IM
Databases
GENBANK
J03027
External Links
PubMed source DOI: 10.1073/pnas.84.24.9145 PMC Full Text View journal details
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