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PMID: 3486656 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Binding of inositol trisphosphate by a liver microsomal fraction.

The Biochemical journal ·Vol. 233 ·No. 3 ·1986-02-01 ·Pages 929-32

Spät A, Fabiato A, Rubin RP

Abstract

Accumulating evidence suggests that the increase in cytosolic Ca2+ induced by receptor agonists is mediated by inositol 1,4,5-trisphosphate, a product of phospholipase C-mediated breakdown of phosphatidylinositol 4,5-bisphosphate. The present study employs inositol tris[32P]phosphate to demonstrate a specific receptor binding site in a microsomal fraction of rat liver.

MeSH Terms
Animals Binding Sites Inositol 1,4,5-Trisphosphate Inositol Phosphates/metabolism Male Microsomes, Liver/metabolism Rats Rats, Inbred Strains Sugar Phosphates/metabolism
Chemicals
Inositol Phosphates Sugar Phosphates Inositol 1,4,5-Trisphosphate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Spät A
Fabiato A
Rubin R P
References (22)
22 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2330929
Published
1986-02-01
Pages
929-32
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1153121
Subset
IM
Grants
NIADDK NIH HHS · AM 28029 · United States
External Links
PubMed source DOI: 10.1042/bj2330929 PMC Full Text View journal details
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