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PMID: 3488018 Published · ppublish English Journal Article

Transfer of beta-lactamase-associated cefoxitin resistance in Bacteroides fragilis.

Antimicrobial agents and chemotherapy ·Vol. 29 ·No. 5 ·1986-05-00 ·Pages 918-20

Cuchural GJ, Tally FP, Storey JR, Malamy MH

Abstract

A cefoxitin-resistant Bacteroides fragilis isolate, TAL 4170, which inactivates cefoxitin, was able to transfer beta-lactamase-mediated cefoxitin resistance to a susceptible B. fragilis recipient. Cefoxitin-resistant transconjugants acquired a new beta-lactamase with a pI of 8.1 and were able to inactivate cefoxitin and retransfer cefoxitin resistance. No plasmids were detected in the donor or transconjugants.

MeSH Terms
Ampicillin/pharmacology Bacteroides fragilis/drug effects,enzymology,genetics Cefoxitin/pharmacology Isoelectric Focusing Penicillin Resistance beta-Lactamases/metabolism
Chemicals
Cefoxitin Ampicillin beta-Lactamases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cuchural G J
Tally F P
Storey J R
Malamy M H
References (13)
13 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.29.5.918
Published
1986-05-00
Pages
918-20
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC284179
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.29.5.918 PMC Full Text View journal details
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