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PMID: 352951 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Enhancement of lymphocyte blastogenic and delayed hypersensitivity skin responses by indomethacin.

Infection and immunity ·Vol. 20 ·No. 3 ·1978-06-00 ·Pages 627-31

Muscoplat CC, Rakich PM, Thoen CO, Johnson DW

Abstract

Incubation of Mycobacterium bovis-sensitized bovine peripheral blood lymphocytes with concanavalin A or M. bovis purified protein derivative and indomethacin caused a consistent, statistically significant increase in [3H] thymidine uptake as compared to cultures without indomethacin. The kinetics of the response showed that indomethacin must be added to lymphocyte cultures within hours after mitogen or antigen addition for enhancement of [3H]thymidine uptake to occur. Lymphocyte blastogenic responses to purified protein derivative were enhanced in both normal and M. bovis-sensitized lymphocyte cultures. However, enhancement of sensitized lymphocyte responses was significantly (P less than 0.01) greater than that in normal animals. Additionally, indomethacin treatment of M. bovis-sensitized guinea pigs singnificantly augmented delayed skin reactions to tuberculin. Delayed hypersensitive skin reactions were only enhanced when indomethacin was administered simultaneously with tuberculin.

MeSH Terms
Animals Antigens, Bacterial/administration & dosage Cattle Concanavalin A/pharmacology Guinea Pigs Hypersensitivity, Delayed/immunology Immunization Indomethacin/pharmacology Kinetics Lymphocyte Activation/drug effects Mitogens Mycobacterium bovis/immunology
Chemicals
Antigens, Bacterial Mitogens Concanavalin A Indomethacin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Muscoplat C C
Rakich P M
Thoen C O
Johnson D W
References (16)
16 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.20.3.627-631.1978
Published
1978-06-00
Pages
627-31
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421904
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.20.3.627-631.1978 PMC Full Text View journal details
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