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PMID: 3547086 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.

Molecular and cellular biology ·Vol. 7 ·No. 2 ·1987-02-00 ·Pages 932-5

Sawey MJ, Hood AT, Burns FJ, Garte SJ

Abstract

An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.

MeSH Terms
Animals DNA, Neoplasm/genetics Gene Amplification Gene Expression Regulation/radiation effects Neoplasms, Radiation-Induced/genetics Proto-Oncogene Proteins/genetics Proto-Oncogenes RNA, Messenger/genetics Radiation, Ionizing Rats Skin Neoplasms/genetics
Chemicals
DNA, Neoplasm Proto-Oncogene Proteins RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sawey M J
Hood A T
Burns F J
Garte S J
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34 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.2.932-935.1987
Published
1987-02-00
Pages
932-5
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC365153
Subset
IM
Grants
NCI NIH HHS · CA13343 · United States
NCI NIH HHS · CA36342 · United States
NIEHS NIH HHS · ES00260 · United States
External Links
PubMed source DOI: 10.1128/mcb.7.2.932-935.1987 PMC Full Text View journal details
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