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PMID: 35613708 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Accounting for the genetic load in assisted reproductive technology.

Clinical and translational medicine ·Vol. 12 ·No. 5 ·2022-00-00 ·Pages e864

van Oosterhout C, Marcu D, Immler S

Abstract

The genetic load in the human genome has important ramifications for assisted reproductive technology (ART), human reproduction and fertility more generally. Here, we discuss these topics in the light of evolutionary genetic theory, the technological revolution in ART and the advances in the fields of genomics and bioinformatics.

Keywords
assisted reproductive technology deleterious mutations genetic load human fertility
MeSH Terms
Fertility/genetics Genetic Load Humans Reproductive Techniques, Assisted
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
van Oosterhout Cock ORCID
School of Environmental Sciences, University of East Anglia, Norwich, UK.
Marcu Daniel ORCID
School of Biological Sciences, University of East Anglia, Norwich, UK.
Immler Simone ORCID
School of Biological Sciences, University of East Anglia, Norwich, UK.
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Article Info
Journal
Clinical and translational medicine
Abbr.
Clin Transl Med
ISSN
2001-1326
DOI
10.1002/ctm2.864
Published
2022-00-00
Pages
e864
Language
English
Region
United States
NLM ID
101597971
PMCID
PMC9132725
Subset
IM
External Links
PubMed source DOI: 10.1002/ctm2.864 PMC Full Text View journal details
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