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PMID: 3600497 Published · ppublish English Journal Article

The effect of saturation with Zn2+ and other metal ions on the antibacterial activity of ovotransferrin.

Medical microbiology and immunology ·Vol. 176 ·No. 3 ·1987-00-00 ·Pages 123-30

Valenti P, Visca P, Antonini G, Orsi N, Antonini E

Abstract

The antibacterial activity of metal complexes of ovotransferrin was tested "in vitro" against different bacterial species and the Zn2+ saturated ovotransferrin appeared to be the most active by comparison with the apo-protein and other metal complexes. Appropriate controls showed that such an effect was neither due to Zn2+ ions, nor to iron deprivation, but to a specific activity of the Zn-ovotransferrin complex. This antibacterial activity required a direct contact of Zn-ovotransferrin with the bacterial surface. In vivo experiments confirmed the higher antibacterial activity of Zn-ovotransferrin as compared with the apo-form.

MeSH Terms
Animals Bacteria/drug effects Conalbumin/pharmacology Drug Stability Egg Proteins/pharmacology Guinea Pigs Metals/pharmacology Zinc/pharmacology
Chemicals
Egg Proteins Metals Conalbumin Zinc
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Valenti P
Visca P
Antonini G
Orsi N
Antonini E
References (18)
18 references, click to expand
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Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF00193893
Published
1987-00-00
Pages
123-30
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00193893 View journal details
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