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PMID: 3600664 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Individual mouse VL30 elements transferred to rat cells by viral pseudotypes retain their responsiveness to activators of protein kinase C.

Molecular and cellular biology ·Vol. 7 ·No. 6 ·1987-06-00 ·Pages 2296-8

Rodland KD, Brown AM, Magun BE

Abstract

By exploiting the retroviral characteristics of mouse VL30 elements, we transferred individual copies of VL30 to Rat-1 cells by infection. Analysis of clonal isolates containing single VL30 elements integrated into the Rat-1 genome indicates that responsiveness to activators of protein kinase C is an inherent property of at least some of the VL30 sequences.

MeSH Terms
Animals Cell Line Cloning, Molecular DNA, Viral/genetics Enzyme Activation Mice Protein Kinase C/metabolism RNA, Viral/genetics Rats Retroviridae/genetics Transcription, Genetic Transfection
Chemicals
DNA, Viral RNA, Viral Protein Kinase C
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Rodland K D
Brown A M
Magun B E
References (10)
10 references, click to expand
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  2. Organization and expression of endogenous virus-like (VL30) DNA sequences in nontransformed and chemically transformed mouse embryo cells in culture.
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    J Virol. 1982 Jul;43(1):50-8 PMID: 6287016
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    Proc Natl Acad Sci U S A. 1982 Dec;79(23):7317-21 PMID: 6296829
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    J Virol. 1979 Mar;29(3):964-72 PMID: 221684
  6. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus.
    Cell. 1983 May;33(1):153-9 PMID: 6678608
  7. Expression of retroviral sequences and oncogenes in murine hepatocellular tumors.
    Cancer Res. 1986 Apr;46(4 Pt 2):1915-9 PMID: 3004709
  8. Regulation of VL30 gene expression by activators of protein kinase C.
    J Biol Chem. 1986 Apr 15;261(11):5029-33 PMID: 3007488
  9. Rescue of endogenous 30S retroviral sequences from mouse cells by baboon type C virus.
    J Virol. 1978 May;26(2):257-64 PMID: 207887
  10. Structure and expression of mouse VL30 genes.
    Mol Cell Biol. 1983 Dec;3(12):2221-31 PMID: 6318090
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.7.6.2296-2298.1987
Published
1987-06-00
Pages
2296-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC365355
Subset
IM
Grants
NCI NIH HHS · CA39360 · United States
External Links
PubMed source DOI: 10.1128/mcb.7.6.2296-2298.1987 PMC Full Text View journal details
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