Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis.

Molecular & general genetics : MGG ·Vol. 165 ·No. 1 ·1978-09-20 ·Pages 87-93

Steinborn G

Abstract

Selection for defective reversion induction, after UV treatment of E. coli K 12, yielded uvm mutants. These mutants exhibited highly reduced or no UV mutability for all loci tested although they were moderately and normally mutable by X-rays and EMS, respectively. Uvm mutations confer only a slight sensitivity to killing by UV and X-rays and no clear sensitivity to the lethal effect of HN2, EMS or MMS. Growth and viability of untreated uvm cells were normal. The properties of uvm mutants are discussed in relation to those of other relevant mutant types and to some actual problems of induced mutagenesis.

MeSH Terms

DNA Repair Escherichia coli/drug effects,genetics,radiation effects Ethyl Methanesulfonate/pharmacology Mutation/radiation effects Phenotype Ultraviolet Rays X-Rays

Chemicals

Ethyl Methanesulfonate

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Steinborn G

References (38)

38 references, click to expand

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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00270380

Published

1978-09-20

Pages

87-93

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00270380

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Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis.

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