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PMID: 3681 Published · ppublish ger Journal Article

[The role of HCO3- ATPase in H+ /HCO3-Secretion (author's transl)].

Die Bedeutung der HCO3--ATPase in der H+ /HCO3--Sekretion

Klinische Wochenschrift ·Vol. 54 ·No. 3 ·1976-02-01 ·Pages 97-104

Simon B, Knauf H

Abstract

Active buffer transport, e.g. H+ -secretion by stomach and kidney and HCO3--secretion by pancreas and salivary glands, is linked with the presence of a HCO3-stimulated ATP-Phosphohydrolase. In contrast to (Na+ -k+)-ATPase which is considered to be equivalent to the Na+ pump, the HCO3--ATPase requires only one ion for activation and is insensitive to ouabain. The HCO3--ATPase is found in the plasma membrane of the epithelia, but in contrast to the (Na+ -k+)-ATPase it is located in the luminal cell border. The activity of the HCO3--ATPase changes in parallel along with the rate of active buffer transport, a finding which underlines its importance as a transport enzyme. Several disorders of buffer transport are described which are possibly associated with a defect of the HCO3--ATPase system.

MeSH Terms
Adenosine Triphosphatases/physiology Animals Bicarbonates/metabolism Biological Transport, Active Enzyme Inhibitors Epithelial Cells Epithelium/metabolism Gastric Juice/metabolism Gastric Mucosa/metabolism Humans Hydrogen-Ion Concentration Kidney/enzymology Models, Biological Ouabain/pharmacology Pancreas/enzymology,metabolism Phospholipids/physiology Rats Stomach/enzymology Submandibular Gland/enzymology,metabolism
Chemicals
Bicarbonates Enzyme Inhibitors Phospholipids Ouabain Adenosine Triphosphatases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Simon B
Knauf H
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39 references, click to expand
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Article Info
Journal
Klinische Wochenschrift
Abbr.
Klin Wochenschr
ISSN
0023-2173
DOI
10.1007/BF01468786
Published
1976-02-01
Pages
97-104
Language
ger
Region
Germany
NLM ID
2985205R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01468786
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