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PMID: 3708213 Published · ppublish English Journal Article

The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs.

British journal of pharmacology ·Vol. 88 ·No. 1 ·1986-05-00 ·Pages 149-53

Fitzgerald MF, Moncada S, Parente L

Abstract

The release of platelet-activating factor (Paf-acether) and of its inactive precursor/metabolite lyso-platelet activating factor (lyso-Paf) from control and sensitized guinea-pig isolated lungs challenged with antigen was investigated. Control guinea-pig lungs perfused either through the pulmonary circulation or through the airways and challenged with antigen did not release Paf-acether. Sensitized guinea-pig isolated lungs perfused through the pulmonary circulation and challenged with antigen released lyso-Paf but not Paf-acether. Sensitized guinea-pig isolated lungs perfused through the airways and challenged with antigen released three times more lyso-Paf and also Paf-acether. These results support a possible role for Paf-acether in respiratory anaphylaxis in the guinea-pig.

MeSH Terms
Anaphylaxis/metabolism Animals Guinea Pigs In Vitro Techniques Lung/metabolism Male Perfusion Platelet Activating Factor/analogs & derivatives,metabolism Pulmonary Circulation Time Factors
Chemicals
O-deacetyl platelet activating factor Platelet Activating Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fitzgerald M F
Moncada S
Parente L
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21 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1986.tb09481.x
Published
1986-05-00
Pages
149-53
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1917123
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1986.tb09481.x PMC Full Text View journal details
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