Detection of circulating immune complexes in alcoholic liver disease.

Clinical and experimental immunology ·Vol. 34 ·No. 1 ·1978-10-00 ·Pages 28-31

Penner E, Albini B, Milgrom F

Abstract

Sera of twenty-five patients with alcoholic liver disease and forty normal control sera were screened for circulating immune complexes by means of the anti-antibody neutralization test and by Raji-cell membrane immunofluorescence assay. IgG-containing immune complexes were detected in thirteen out of twenty-five patients with alcoholic liver diseases and in one out of forty normal individuals; in addition, IgA-containing complexes were demonstrated in seven out of thirteen sera positive for IgG complexes. The presence of immune complexes was restricted to alcoholic hepatitis and active cirrhosis, thus indicating a relationship with disease severity.

MeSH Terms

Antigen-Antibody Complex Fluorescent Antibody Technique Hepatitis, Alcoholic/immunology Humans Immunoglobulin A/analysis Immunoglobulin G/analysis Liver Cirrhosis, Alcoholic/immunology Liver Diseases, Alcoholic/immunology Neutralization Tests

Chemicals

Antigen-Antibody Complex Immunoglobulin A Immunoglobulin G

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Penner E

Albini B

Milgrom F

References (13)

13 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1978-10-00

Pages

28-31

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1537457

Subset

External Links

PubMed source PMC Full Text View journal details

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Detection of circulating immune complexes in alcoholic liver disease.

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