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PMID: 3739623 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Enteric nerves in diabetic rats: electron microscopic evidence for neuropathy of vasoactive intestinal polypeptide-containing fibres.

Acta neuropathologica ·Vol. 70 ·No. 2 ·1986-00-00 ·Pages 161-8

Loesch A, Belai A, Lincoln J, Burnstock G

Abstract

Enteric nerves in the ileum of rats 8 weeks after streptozotocin-induction of diabetes were examined under the electron microscope before and after immunolabeling for vasoactive intestinal polypeptide (VIP). These studies have provided evidence of degenerative changes in the myenteric nerve fibres of diabetic rats, many of which were shown to contain VIP. It is suggested that VIP-ergic nerves in the gut may play a role in the development of gastrointestinal dysfunction in diabetes.

MeSH Terms
Animals Diabetes Mellitus, Experimental/pathology Diabetic Neuropathies/pathology Ileum/innervation Male Microscopy, Electron Myenteric Plexus/pathology Rats Rats, Inbred Strains Vasoactive Intestinal Peptide/physiology
Chemicals
Vasoactive Intestinal Peptide
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Loesch A
Belai A
Lincoln J
Burnstock G
References (34)
34 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00691434
Published
1986-00-00
Pages
161-8
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00691434 View journal details
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