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PMID: 3783816 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1.

Journal of virology ·Vol. 60 ·No. 3 ·1986-12-00 ·Pages 1153-5

Schlesinger JJ, Brandriss MW, Cropp CB, Monath TP

Abstract

Immunization of monkeys with yellow fever virus-specified nonstructural protein NS1 resulted in protection against fatal hepatitis as well as marked reduction in the magnitude of viremia after subcutaneous challenge with yellow fever virus. The results may be relevant to the design of possible subunit or recombinant flavivirus vaccines.

MeSH Terms
Animals Antigens, Viral/immunology Complement Activation Glycoproteins/immunology Immunization Macaca mulatta Neutralization Tests Viral Proteins/immunology Yellow Fever/prevention & control Yellow fever virus/immunology
Chemicals
Antigens, Viral Glycoproteins Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schlesinger J J
Brandriss M W
Cropp C B
Monath T P
References (9)
9 references, click to expand
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    J Immunol. 1985 Oct;135(4):2805-9 PMID: 4031501
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.60.3.1153-1155.1986
Published
1986-12-00
Pages
1153-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253373
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.60.3.1153-1155.1986 PMC Full Text View journal details
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