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PMID: 3862090 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Quantitative and qualitative changes in histone gene expression during early mouse embryo development.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 17 ·1985-09-00 ·Pages 5685-9

Graves RA, Marzluff WF, Giebelhaus DH, Schultz GA

Abstract

There are large amounts of histone mRNA present in mouse eggs. These RNAs are rapidly degraded, as are other mRNAs, after fertilization and prior to the second cleavage. During cleavage, the histone mRNA accumulates as the embryo divides. The same sets of histone genes are expressed in eggs and embryos, although there are large qualitative differences in the amounts of particular histone mRNAs. The function of the egg histone mRNA is unknown. The amount of histone mRNA in cleaving and blastocyst embryos is probably sufficient to code for the blastocyst histone proteins.

MeSH Terms
Animals Blastocyst/physiology Female Gene Expression Regulation Histones/genetics Mice/embryology,genetics Nucleic Acid Hybridization Ovum/physiology RNA, Messenger/metabolism Zygote/physiology
Chemicals
Histones RNA, Messenger
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Graves R A
Marzluff W F
Giebelhaus D H
Schultz G A
References (26)
26 references, click to expand
  1. Histone synthesis in early amphibian development: histone and DNA syntheses are not co-ordinated.
    J Mol Biol. 1974 Sep 15;88(2):263-85 PMID: 4476799
  2. Differential expression of two clusters of mouse histone genes.
    J Mol Biol. 1985 May 25;183(2):179-94 PMID: 2989540
  3. Methylmercury as a reversible denaturing agent for agarose gel electrophoresis.
    Anal Biochem. 1976 Jan;70(1):75-85 PMID: 1259158
  4. Amplification and characterization of a beta-globin gene synthesized in vitro.
    Cell. 1976 Jun;8(2):163-82 PMID: 61066
  5. The synthesis and storage of histones during the oogenesis of Xenopus laevis.
    Dev Biol. 1977 May;57(1):118-35 PMID: 558925
  6. Stored and polysomal ribosomes of mouse ova.
    Dev Biol. 1977 Jul 15;58(2):248-54 PMID: 560325
  7. Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5350-4 PMID: 414220
  8. Poly(A) and synthesis of polyadenylated RNA in the preimplantation mouse embryo.
    Dev Biol. 1978 May;64(1):140-8 PMID: 658592
  9. Stage-specific mRNAs coding for subtypes of H2A and H2B histones in the sea urchin embryo.
    Cell. 1978 Jun;14(2):327-36 PMID: 667944
  10. Histone gene expression during sea urchin embryogenesis: isolation and characterization of early and late messenger RNAs of Strongylocentrotus purpuratus by gene-specific hybridization and template activity.
    Dev Biol. 1979 Nov;73(1):153-73 PMID: 527767
  11. Changing rates of histone mRNA synthesis and turnover in Drosophila embryos.
    Cell. 1980 Oct;21(3):717-27 PMID: 6777046
  12. Accumulation of histone repeat transcripts in the sea urchin egg pronucleus.
    Cell. 1981 May;24(2):385-91 PMID: 7195316
  13. The rate of synthesis of histone mRNA during the development of sea urchin embryos (Strongylocentrotus purpuratus).
    Dev Biol. 1981 Apr 30;83(2):380-6 PMID: 7239020
  14. Evidence for expression of the paternal genome in the two-cell mouse embryo.
    Nature. 1981 Dec 3;294(5840):450-1 PMID: 6171732
  15. Quantitative changes in total RNA, total poly(A), and ribosomes in early mouse embryos.
    Dev Biol. 1982 Feb;89(2):362-78 PMID: 6173273
  16. Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.
    Proc Natl Acad Sci U S A. 1983 Apr;80(7):1849-53 PMID: 6572946
  17. Changes in the quantity of histone and actin messenger RNA during the development of preimplantation mouse embryos.
    Dev Biol. 1983 Jul;98(1):148-54 PMID: 6407884
  18. Uncoordinated synthesis of histones and DNA by mouse eggs and preimplantation embryos.
    J Exp Zool. 1983 May;226(2):231-7 PMID: 6864179
  19. Rabbit alpha-globin messenger RNA translation by the mouse ovum.
    J Embryol Exp Morphol. 1983 Apr;74:159-68 PMID: 6684144
  20. Structure of a cluster of mouse histone genes.
    Nucleic Acids Res. 1983 Oct 11;11(19):6679-97 PMID: 6314253
  21. Rapid reversible changes in the rate of histone gene transcription and histone mRNA levels in mouse myeloma cells.
    Mol Cell Biol. 1984 Feb;4(2):351-7 PMID: 6700595
  22. The relationship between cleavage, DNA replication, and gene expression in the mouse 2-cell embryo.
    J Embryol Exp Morphol. 1984 Feb;79:139-63 PMID: 6716041
  23. The transition from maternal to embryonic control in the 2-cell mouse embryo.
    EMBO J. 1982;1(6):681-6 PMID: 7188357
  24. Are there major developmentally regulated H4 gene classes in Xenopus?
    Nucleic Acids Res. 1984 Jun 25;12(12):4939-58 PMID: 6330691
  25. Actin mRNA content in normal and delayed implanting mouse embryos.
    Dev Biol. 1985 Feb;107(2):407-13 PMID: 3972162
  26. Mouse sperm basic nuclear protein. Electrophoretic characterization and fate after fertilization.
    J Cell Biol. 1975 Aug;66(2):251-62 PMID: 1141382
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.17.5685
Published
1985-09-00
Pages
5685-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC390616
Subset
IM
Grants
NIGMS NIH HHS · GM29832 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.17.5685 PMC Full Text View journal details
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