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PMID: 3878690 Published · ppublish English Journal Article

Cephamycin inactivation due to enzymatic hydrolysis by beta-lactamase from Bacteroides fragilis.

Antimicrobial agents and chemotherapy ·Vol. 28 ·No. 6 ·1985-12-00 ·Pages 773-7

Yotsuji A, Minami S, Kakizawa H, Yasuda T, Takai A, Saikawa I, Inoue M, Mitsuhashi S

Abstract

The susceptibility of 53 clinical isolates of Bacteroides fragilis to cephamycins was examined. Judging from the MICs for 50% of the strains tested, moxalactam was the most active, however, judging from the MICs for 90% of the strains tested, cefbuperazone was more effective than moxalactam. A correlation was observed between in vitro activity of benzylpenicillin and cephaloridine and beta-lactamase production. Inactivation due to enzymatic hydrolysis of cephamycins over a short time was not observed; however, inactivation was detected by a double disk diffusion test, and moxalactam was most easily inactivated. We conclude that inactivation due to enzymatic hydrolysis of cephamycins over a long time may play an important role in resistance to some cephamycins in strains of B. fragilis.

MeSH Terms
Bacteroides fragilis/drug effects,enzymology Cephalosporins/metabolism,pharmacology Cephamycins/metabolism,pharmacology Clavulanic Acid Clavulanic Acids/pharmacology Hydrolysis Microbial Sensitivity Tests Moxalactam/pharmacology Penicillin G/pharmacology beta-Lactamase Inhibitors beta-Lactamases/metabolism
Chemicals
Cephalosporins Cephamycins Clavulanic Acids beta-Lactamase Inhibitors Clavulanic Acid beta-Lactamases Penicillin G Moxalactam
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Yotsuji A
Minami S
Kakizawa H
Yasuda T
Takai A
Saikawa I
Inoue M
Mitsuhashi S
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19 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.28.6.773
Published
1985-12-00
Pages
773-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180326
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.28.6.773 PMC Full Text View journal details
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