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PMID: 3879767 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Interleukin 1 regulates human metallothionein gene expression.

Molecular and cellular biology ·Vol. 5 ·No. 10 ·1985-10-00 ·Pages 2866-9

Karin M, Imbra RJ, Heguy A, Wong G

Abstract

Incubation of cultured human cells with interleukin 1 leads to increased expression of the human metallothionein-IIA gene. Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals.

MeSH Terms

Animals Cells, Cultured Dose-Response Relationship, Drug Gene Expression Regulation Humans Interleukin-1/pharmacology Metallothionein/genetics Mice Species Specificity

Chemicals

Interleukin-1 Metallothionein

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Karin M

Imbra R J

Heguy A

Wong G

References (31)

31 references, click to expand

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Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.5.10.2866-2869.1985

Published

1985-10-00

Pages

2866-9

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC367029

Subset

External Links

PubMed source DOI: 10.1128/mcb.5.10.2866-2869.1985 PMC Full Text View journal details

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