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PMID: 3886670 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Active maturation-promoting factor is present in mature mouse oocytes.

The Journal of cell biology ·Vol. 100 ·No. 5 ·1985-05-00 ·Pages 1637-40

Sorensen RA, Cyert MS, Pedersen RA

Abstract

Cytoplasmic extracts of meiotically mature mouse oocytes were injected into immature Xenopus laevis oocytes, which underwent germinal vesicle breakdown within 2 h. Germinal vesicle breakdown was not inhibited by incubation of the Xenopus oocytes in cycloheximide (20 micrograms/ml). Identically prepared extracts of meiotically immature mouse oocytes, arrested at the germinal vesicle stage by dibutyryl cyclic AMP (100 micrograms/ml), did not induce germinal vesicle breakdown in Xenopus oocytes. The results show that maturation-promoting factor activity appears during the course of oocyte maturation in the mouse.

MeSH Terms
Animals Female Growth Substances/physiology Maturation-Promoting Factor Meiosis Mice/physiology Oocytes/physiology Xenopus laevis
Chemicals
Growth Substances Maturation-Promoting Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sorensen R A
Cyert M S
Pedersen R A
References (24)
24 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.100.5.1637
Published
1985-05-00
Pages
1637-40
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2113872
Subset
IM
Grants
NIGMS NIH HHS · T-32-GM-07810 · United States
External Links
PubMed source DOI: 10.1083/jcb.100.5.1637 PMC Full Text View journal details
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